HCSGD entry for PGGT1B

1. General information

Official gene symbolPGGT1B
Entrez ID5229
Gene full nameprotein geranylgeranyltransferase type I, beta subunit
Other gene symbolsBGGI GGTI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004661Protein geranylgeranyltransferase activityIDAmolecular_function
GO:0004662CAAX-protein geranylgeranyltransferase activityISSmolecular_function
GO:0005953CAAX-protein geranylgeranyltransferase complexIDAcellular_component
GO:0008270Zinc ion bindingISSmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0018344Protein geranylgeranylationIDAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0045787Positive regulation of cell cycleIEAbiological_process
GO:0051771Negative regulation of nitric-oxide synthase biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83517301010.12654874050.99999024730.6848387256

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0865868419
GSE13712_SHEARUp0.1970562389
GSE13712_STATICUp0.1433873069
GSE19018Down-0.4874222480
GSE19899_A1Down-0.2030450286
GSE19899_A2Down-0.3125488170
PubMed_21979375_A1Up0.6167057648
PubMed_21979375_A2Down-0.3783433026
GSE35957Down-0.1476948943
GSE36640Up0.1712194569
GSE54402Down-0.2151818336
GSE9593Down-0.1084085396
GSE43922Down-0.1093172037
GSE24585Up0.0607793829
GSE37065Down-0.0165173169
GSE28863_A1Up0.2228304501
GSE28863_A2Up0.0844449619
GSE28863_A3Down-0.3142481379
GSE28863_A4Down-0.0828292091
GSE48662Down-0.1189203385

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILEDB07227 -
GERANYLGERANYL DIPHOSPHATEDB07841 -
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATEDB08180 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022675MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.