HCSGD entry for PLA2G2A
1. General information
| Official gene symbol | PLA2G2A |
|---|---|
| Entrez ID | 5320 |
| Gene full name | phospholipase A2, group IIA (platelets, synovial fluid) |
| Other gene symbols | MOM1 PLA2 PLA2B PLA2L PLA2S PLAS1 sPLA2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004623 | Phospholipase A2 activity | IDA TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005543 | Phospholipid binding | IDA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006644 | Phospholipid metabolic process | IDA TAS | biological_process |
| GO:0006654 | Phosphatidic acid biosynthetic process | TAS | biological_process |
| GO:0010744 | Positive regulation of macrophage derived foam cell differentiation | TAS | biological_process |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
| GO:0030141 | Secretory granule | IEA | cellular_component |
| GO:0034374 | Low-density lipoprotein particle remodeling | TAS | biological_process |
| GO:0036148 | Phosphatidylglycerol acyl-chain remodeling | TAS | biological_process |
| GO:0036149 | Phosphatidylinositol acyl-chain remodeling | TAS | biological_process |
| GO:0036150 | Phosphatidylserine acyl-chain remodeling | TAS | biological_process |
| GO:0036151 | Phosphatidylcholine acyl-chain remodeling | TAS | biological_process |
| GO:0036152 | Phosphatidylethanolamine acyl-chain remodeling | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046473 | Phosphatidic acid metabolic process | IDA | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0047498 | Calcium-dependent phospholipase A2 activity | TAS | molecular_function |
| GO:0050729 | Positive regulation of inflammatory response | TAS | biological_process |
| GO:0050830 | Defense response to Gram-positive bacterium | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4462443410 | 0.2484350443 | 0.9999902473 | 0.9582442556 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0378280871 |
| GSE13712_SHEAR | Down | -0.1633164359 |
| GSE13712_STATIC | Down | -0.2969429113 |
| GSE19018 | Down | -0.2965718723 |
| GSE19899_A1 | Down | -0.0268993497 |
| GSE19899_A2 | Down | -0.0965284933 |
| PubMed_21979375_A1 | Down | -0.2706227847 |
| PubMed_21979375_A2 | Up | 0.1760162965 |
| GSE35957 | Down | -0.0038984752 |
| GSE36640 | Down | -0.0400652012 |
| GSE54402 | Down | -0.0401811180 |
| GSE9593 | Down | -0.4665604449 |
| GSE43922 | Up | 0.1612119734 |
| GSE24585 | Up | 0.0439489562 |
| GSE37065 | Down | -0.2242063472 |
| GSE28863_A1 | Up | 0.9902956988 |
| GSE28863_A2 | Up | 0.0647619626 |
| GSE28863_A3 | Up | 0.2736247870 |
| GSE28863_A4 | Up | 0.0632409096 |
| GSE48662 | Down | -0.0510548546 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Indomethacin | DB00328 | APRD00109 |
| Diclofenac | DB00586 | APRD00527 |
| Ginkgo biloba | DB01381 | - |
| 1,4-Butanediol | DB01955 | EXPT00771 |
| 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene | DB02080 | EXPT03116 |
| Isopropyl Alcohol | DB02325 | EXPT01912 | DB04402 |
| N-Tridecanoic Acid | DB02448 | EXPT03028 |
| [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid | DB02504 | EXPT00335 |
| 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid | DB02936 | EXPT00286 |
| 1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid | DB03121 | EXPT01810 |
| 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid | DB03471 | EXPT00747 |
| Elaidoylamide | DB03784 | EXPT01336 |
| 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide | DB04112 | EXPT01881 |
| (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid | DB04287 | EXPT00701 |
| Suramin | DB04786 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19264704 | Secretory phospholipase A(2) (sPLA(2)) is involved in various cellular physiological and pathological responses, especially in inflammatory responses |
| 19264704 | In this study, we found that sPLA(2) treatment induces cellular senescence in human dermal fibroblasts (HDFs), as confirmed by increases in senescence-associated beta-galactosidase activity, changes in cell morphology, and upregulation of p53/p21 protein levels |
| 19264704 | Treatment with sPLA(2) increases reactive oxygen species (ROS) production, and an antioxidant, N-acetylcysteine, inhibits sPLA(2)-induced cellular senescence |
| 19264704 | These results suggest that sPLA(2) has a role in cellular senescence in HDFs during inflammatory response by promoting ROS-dependent p53 activation and might therefore contribute to inflammatory disorders associated with aging |
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