HCSGD entry for POLH
1. General information
| Official gene symbol | POLH |
|---|---|
| Entrez ID | 5429 |
| Gene full name | polymerase (DNA directed), eta |
| Other gene symbols | RAD30 RAD30A XP-V XPV |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000731 | DNA synthesis involved in DNA repair | IDA | biological_process |
| GO:0003684 | Damaged DNA binding | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006282 | Regulation of DNA repair | TAS | biological_process |
| GO:0006290 | Pyrimidine dimer repair | IEA | biological_process |
| GO:0006301 | Postreplication repair | IEA | biological_process |
| GO:0010225 | Response to UV-C | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0334303522 | 0.8924947228 | 0.4200096897 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0326090978 |
| GSE13712_SHEAR | Up | 0.6952682148 |
| GSE13712_STATIC | Up | 0.3906284983 |
| GSE19018 | Up | 0.2759880146 |
| GSE19899_A1 | Up | 0.0207452700 |
| GSE19899_A2 | Up | 0.0838364205 |
| PubMed_21979375_A1 | Up | 0.0965656524 |
| PubMed_21979375_A2 | Down | -0.2020818243 |
| GSE35957 | Up | 0.4802187495 |
| GSE36640 | Up | 0.1302434006 |
| GSE54402 | Down | -0.4089876116 |
| GSE9593 | Up | 0.0610970370 |
| GSE43922 | Up | 0.0270996820 |
| GSE24585 | Up | 1.0724622848 |
| GSE37065 | Down | -0.1291848077 |
| GSE28863_A1 | Up | 0.7252905734 |
| GSE28863_A2 | Up | 0.0930492146 |
| GSE28863_A3 | Down | -0.0751973023 |
| GSE28863_A4 | Down | -0.0193892255 |
| GSE48662 | Up | 0.4813587952 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-183-5p | MIMAT0000261 | MIRT047103 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26240351 | Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities |
| 26240351 | DNA polymerase eta (pol eta), encoded by the xeroderma pigmentosum (XP-V) gene, plays an essential role in preventing cutaneous cancer caused by UV radiation-induced DNA damage |
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