HCSGD entry for POLR2D
1. General information
| Official gene symbol | POLR2D |
|---|---|
| Entrez ID | 5433 |
| Gene full name | polymerase (RNA) II (DNA directed) polypeptide D |
| Other gene symbols | HSRBP4 HSRPB4 RBP4 RPB16 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003899 | DNA-directed RNA polymerase activity | IEA IMP | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005665 | DNA-directed RNA polymerase II, core complex | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA IMP TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006368 | Transcription elongation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006370 | 7-methylguanosine mRNA capping | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0050434 | Positive regulation of viral transcription | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3338045059 | 0.1920643175 | 0.9999902473 | 0.8508943463 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0551164256 |
| GSE13712_SHEAR | Up | 0.4602063007 |
| GSE13712_STATIC | Up | 0.5528833551 |
| GSE19018 | Down | -0.7594540205 |
| GSE19899_A1 | Up | 0.0841809845 |
| GSE19899_A2 | Up | 0.0170435121 |
| PubMed_21979375_A1 | Up | 0.4865011529 |
| PubMed_21979375_A2 | Down | -0.3472446245 |
| GSE35957 | Down | -0.6569449496 |
| GSE36640 | Down | -1.1980278366 |
| GSE54402 | Up | 0.6093849769 |
| GSE9593 | Down | -0.2889524809 |
| GSE43922 | Up | 0.1904664954 |
| GSE24585 | Down | -0.1114786753 |
| GSE37065 | Up | 0.1226017420 |
| GSE28863_A1 | Up | 0.0821509298 |
| GSE28863_A2 | Up | 0.2971503864 |
| GSE28863_A3 | Down | -0.2669774030 |
| GSE28863_A4 | Down | -0.1424593077 |
| GSE48662 | Down | -0.3467305765 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-421 | MIMAT0003339 | MIRT016121 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026057 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030510 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032142 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036289 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045220 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
