HCSGD entry for POLR2K

1. General information

Official gene symbolPOLR2K
Entrez ID5440
Gene full namepolymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
Other gene symbolsABC10-alpha RPABC4 RPB10alpha RPB12 RPB7.0 hRPB7.0 hsRPB10a
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000398MRNA splicing, via spliceosomeTASbiological_process
GO:0001054RNA polymerase I activityIBAmolecular_function
GO:0001055RNA polymerase II activityIBAmolecular_function
GO:0001056RNA polymerase III activityIBAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003899DNA-directed RNA polymerase activityIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005665DNA-directed RNA polymerase II, core complexIDAcellular_component
GO:0005666DNA-directed RNA polymerase III complexIBAcellular_component
GO:0005736DNA-directed RNA polymerase I complexIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006289Nucleotide-excision repairTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006356Regulation of transcription from RNA polymerase I promoterTASbiological_process
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterTASbiological_process
GO:0006362Transcription elongation from RNA polymerase I promoterTASbiological_process
GO:0006363Termination of RNA polymerase I transcriptionTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0006383Transcription from RNA polymerase III promoterTASbiological_process
GO:0006385Transcription elongation from RNA polymerase III promoterTASbiological_process
GO:0006386Termination of RNA polymerase III transcriptionTASbiological_process
GO:0008270Zinc ion bindingTASmolecular_function
GO:0008380RNA splicingTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0050434Positive regulation of viral transcriptionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88465126320.24730518600.99999024730.9565988246

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3043159141
GSE13712_SHEARDown-0.0451182492
GSE13712_STATICDown-0.0504552662
GSE19018Down-0.2201005042
GSE19899_A1Down-0.0033413927
GSE19899_A2Down-0.3203787488
PubMed_21979375_A1Down-0.1588345548
PubMed_21979375_A2Down-0.1074515350
GSE35957Down-0.1198396468
GSE36640Up0.0044932450
GSE54402Down-0.0531396769
GSE9593Down-0.1891537715
GSE43922Down-0.0485885353
GSE24585Down-0.0315230308
GSE37065Up0.1438526221
GSE28863_A1Down-0.2272656170
GSE28863_A2Up0.4413020465
GSE28863_A3Down-0.1798391552
GSE28863_A4Down-0.0881871897
GSE48662Down-0.2480350667

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002738Microarray//Microarray;OtherFunctional MTI (Weak)15685193
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.