HCSGD entry for XRN1
1. General information
| Official gene symbol | XRN1 |
|---|---|
| Entrez ID | 54464 |
| Gene full name | 5'-3' exoribonuclease 1 |
| Other gene symbols | SEP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000932 | Cytoplasmic mRNA processing body | IEA | cellular_component |
| GO:0000956 | Nuclear-transcribed mRNA catabolic process | IMP | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004527 | Exonuclease activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0008409 | 5'-3' exonuclease activity | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016075 | RRNA catabolic process | IMP | biological_process |
| GO:0043928 | Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | TAS | biological_process |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0071028 | Nuclear mRNA surveillance | IMP | biological_process |
| GO:0071044 | Histone mRNA catabolic process | IMP | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1121280802 | 0.1271427415 | 0.6913692074 | 0.6864115669 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2951301497 |
| GSE13712_SHEAR | Down | -0.0036182978 |
| GSE13712_STATIC | Up | 0.0286325053 |
| GSE19018 | Up | 0.2974292552 |
| GSE19899_A1 | Down | -0.3162579691 |
| GSE19899_A2 | Down | -0.4354180508 |
| PubMed_21979375_A1 | Down | -1.2213317668 |
| PubMed_21979375_A2 | Down | -0.5480573186 |
| GSE35957 | Up | 0.2085490778 |
| GSE36640 | Up | 0.3814760445 |
| GSE54402 | Down | -0.2442897784 |
| GSE9593 | Up | 0.2265131204 |
| GSE43922 | Down | -0.5355470103 |
| GSE24585 | Up | 0.4014971566 |
| GSE37065 | Up | 0.4788804629 |
| GSE28863_A1 | Up | 0.9369349800 |
| GSE28863_A2 | Up | 1.2574224357 |
| GSE28863_A3 | Down | -0.1501936635 |
| GSE28863_A4 | Down | -0.2912953178 |
| GSE48662 | Up | 0.2449465782 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017527 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025425 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT025621 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032310 | Proteomics | Functional MTI (Weak) | 18668040 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 9218715 | Cloning and characterization of mouse Dhm2 cDNA, a functional homolog of budding yeast SEP1 |
| 9218715 | We have isolated mouse Dhm2 cDNAs encoding a homolog of budding yeast SEP1, whose product is involved in many cellular processes including meiosis, cellular senescence, and telomere maintenance |
| 9218715 | A multicopy plasmid containing of the Dhm2 cDNA complements the slow growth phenotype, sporulation defect, and DNA recombination defect caused by the sep1 mutation in yeast, indicating that Dhm2 is a functional homolog of SEP1 |
| 9218715 | Since Dhm1, another SEP1 homolog we reported previously, only partially compensates for the sep1 mutation, we conclude that Dhm2 is a true homolog of SEP1 |
| 7597069 | The yeast gene KEM1 (also named SEP1/DST2/XRN1/RAR5) produces a G4-DNA-dependent nuclease that binds to G4 tetraplex DNA structure and cuts in a single-stranded region 5' to the G4 structure |
Entries Per Page
Displaying Page of
