HCSGD entry for PAF1
1. General information
| Official gene symbol | PAF1 |
|---|---|
| Entrez ID | 54623 |
| Gene full name | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) |
| Other gene symbols | F23149_1 PD2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0000993 | RNA polymerase II core binding | IDA | molecular_function |
| GO:0001711 | Endodermal cell fate commitment | ISS | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006378 | MRNA polyadenylation | IMP | biological_process |
| GO:0010390 | Histone monoubiquitination | IDA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016593 | Cdc73/Paf1 complex | IDA | cellular_component |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0031442 | Positive regulation of mRNA 3'-end processing | IMP | biological_process |
| GO:0032968 | Positive regulation of transcription elongation from RNA polymerase II promoter | IDA | biological_process |
| GO:0033523 | Histone H2B ubiquitination | IDA | biological_process |
| GO:0045638 | Negative regulation of myeloid cell differentiation | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0071222 | Cellular response to lipopolysaccharide | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9044420767 | 0.1183774477 | 0.9999902473 | 0.6611102907 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0605176421 |
| GSE13712_SHEAR | Up | 0.0543815588 |
| GSE13712_STATIC | Up | 0.1589833487 |
| GSE19018 | Down | -0.6015238963 |
| GSE19899_A1 | Down | -0.1675011413 |
| GSE19899_A2 | Down | -0.1569262992 |
| PubMed_21979375_A1 | Down | -0.4538482473 |
| PubMed_21979375_A2 | Down | -0.4437903655 |
| GSE35957 | Down | -0.2979854138 |
| GSE36640 | Down | -0.4759741342 |
| GSE54402 | Down | -0.2275142761 |
| GSE9593 | Down | -0.0981569726 |
| GSE43922 | Down | -0.0987063294 |
| GSE24585 | Up | 0.0635859131 |
| GSE37065 | Down | -0.0650767718 |
| GSE28863_A1 | Up | 0.1911771946 |
| GSE28863_A2 | Down | -0.0597649440 |
| GSE28863_A3 | Up | 0.0393255489 |
| GSE28863_A4 | Up | 0.2773180425 |
| GSE48662 | Down | -0.0088982920 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029230 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030422 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036116 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036438 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040209 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044571 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
