HCSGD entry for TET2
1. General information
| Official gene symbol | TET2 |
|---|---|
| Entrez ID | 54790 |
| Gene full name | tet methylcytosine dioxygenase 2 |
| Other gene symbols | KIAA1546 MDS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006493 | Protein O-linked glycosylation | IDA IEA IMP | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0030099 | Myeloid cell differentiation | IEA IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0070579 | Methylcytosine dioxygenase activity | IEA IMP ISS | molecular_function |
| GO:0080111 | DNA demethylation | IEA | biological_process |
| GO:0080182 | Histone H3-K4 trimethylation | IEA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9395957600 | 0.0842316933 | 0.9999902473 | 0.5513778413 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2006271681 |
| GSE13712_SHEAR | Up | 0.1447934490 |
| GSE13712_STATIC | Up | 0.0176294664 |
| GSE19018 | Up | 0.0289406549 |
| GSE19899_A1 | Down | -0.1123760331 |
| GSE19899_A2 | Down | -0.4994519657 |
| PubMed_21979375_A1 | Down | -0.4145282570 |
| PubMed_21979375_A2 | Up | 0.0999427622 |
| GSE35957 | Down | -0.2355251555 |
| GSE36640 | Down | -0.3968507884 |
| GSE54402 | Up | 0.1003026972 |
| GSE9593 | Down | -0.2003879597 |
| GSE43922 | Down | -0.1700765622 |
| GSE24585 | Up | 0.4170305868 |
| GSE37065 | Up | 0.1723303630 |
| GSE28863_A1 | Up | 0.0231322902 |
| GSE28863_A2 | Down | -0.2083783377 |
| GSE28863_A3 | Down | -0.4822910145 |
| GSE28863_A4 | Down | -0.4015439161 |
| GSE48662 | Down | -0.0494889383 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016981 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-484 | MIMAT0002174 | MIRT042185 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049648 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27147278 | Prominent examples include aberrations in cytokines and their signaling pathways (such as tumor necrosis factor-alpha, interferon-gamma, SMAD proteins), mutations in genes encoding the RNA splicing machinery (SF3B1, SRSF2, ZRSR2, and U2AF1 genes), mutations in genes disrupting the epigenetic machinery (TET2, DNMT3A, DNMT3B, EZH2, ASXL1) |
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