HCSGD entry for PRMT6
1. General information
| Official gene symbol | PRMT6 |
|---|---|
| Entrez ID | 55170 |
| Gene full name | protein arginine methyltransferase 6 |
| Other gene symbols | HRMT1L6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006284 | Base-excision repair | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016571 | Histone methylation | IDA | biological_process |
| GO:0019919 | Peptidyl-arginine methylation, to asymmetrical-dimethyl arginine | IDA | biological_process |
| GO:0034970 | Histone H3-R2 methylation | IDA | biological_process |
| GO:0035241 | Protein-arginine omega-N monomethyltransferase activity | IDA | molecular_function |
| GO:0035242 | Protein-arginine omega-N asymmetric methyltransferase activity | IDA | molecular_function |
| GO:0042054 | Histone methyltransferase activity | IDA | molecular_function |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0043985 | Histone H4-R3 methylation | IDA | biological_process |
| GO:0044020 | Histone methyltransferase activity (H4-R3 specific) | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0070611 | Histone methyltransferase activity (H3-R2 specific) | IDA | molecular_function |
| GO:0070612 | Histone methyltransferase activity (H2A-R3 specific) | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9344259527 | 0.0251521979 | 0.9999902473 | 0.3051042377 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2498677723 |
| GSE13712_SHEAR | Down | -0.1788215186 |
| GSE13712_STATIC | Down | -0.1314268472 |
| GSE19018 | Down | -1.0262390883 |
| GSE19899_A1 | Up | 0.2256947985 |
| GSE19899_A2 | Up | 0.1169158062 |
| PubMed_21979375_A1 | Up | 0.1365935566 |
| PubMed_21979375_A2 | Down | -0.0015362704 |
| GSE35957 | Down | -0.7905972126 |
| GSE36640 | Down | -1.1709570876 |
| GSE54402 | Up | 0.4718762948 |
| GSE9593 | Down | -0.6121972148 |
| GSE43922 | Up | 0.0498883117 |
| GSE24585 | Down | -0.4778627291 |
| GSE37065 | Up | 0.0111684288 |
| GSE28863_A1 | Down | -0.0240773466 |
| GSE28863_A2 | Up | 0.0505629968 |
| GSE28863_A3 | Down | -0.4243837464 |
| GSE28863_A4 | Down | -0.0450099078 |
| GSE48662 | Down | -0.4581102807 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22987071 | Here, we report that protein arginine methyltransferase 6 (PRMT6), a type I PRMT known to act as a transcriptional cofactor, directly represses the p21 promoter |
| 22987071 | PRMT6 knock-down (KD) results in a p21 derepression in breast cancer cells, which is p53-independent, and leads to cell cycle arrest, cellular senescence and reduced growth in soft agar assays and in severe combined immunodeficiency (SCID) mice for all the cancer lines examined |
| 22987071 | We conclude that PRMT6 acts as an oncogene in breast cancer cells, promoting growth and preventing senescence, making it an attractive target for cancer therapy |
| 22904064 | Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor |
| 22904064 | Protein arginine methyltransferase 6 (PRMT6) has been shown to function as a transcriptional repressor by methylating the histone H3 arginine 2 [H3R2(me2a)] repressive mark; however, few targets are known |
| 22904064 | To define the physiological role of PRMT6 and to identify its targets, we generated PRMT6(-/-) mouse embryo fibroblasts (MEFs) |
| 22904064 | We observed that early passage PRMT6(-/-) MEFs had growth defects and exhibited the hallmarks of cellular senescence |
| 22904064 | PRMT6(-/-) MEFs displayed high transcriptional levels of p53 and its targets, p21 and PML |
| 22904064 | Generation of PRMT6(-/-); p53(-/-) MEFs prevented the premature senescence, suggesting that the induction of senescence is p53-dependent |
| 22904064 | Using chromatin immunoprecipitation assays, we observed an enrichment of PRMT6 and H3R2(me2a) within the upstream region of Trp53 |
| 22904064 | The PRMT6 association and the H3R2(me2a) mark were lost in PRMT6(-/-) MEFs and an increase in the H3K4(me3) activator mark was observed |
| 22904064 | Our findings define a new regulator of p53 transcriptional regulation and define a role for PRMT6 and arginine methylation in cellular senescence |
| 18676353 | When the expression of protein arginine methyltransferases (PRMTs), namely PRMT1, PRMT4, PRMT5 and PRMT6 was examined, a significant reduction was found in replicatively senescent cells as well as their catalytic activities against histone mixtures compared with the young cells |
| 18676353 | Furthermore, when the endogenous level of arginine-dimethylated proteins was determined, asymmetric modification (the product of type I PRMTs including PRMT1, PRMT4 and PRMT6) was markedly down-regulated |
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