HCSGD entry for PPP3CA

1. General information

Official gene symbolPPP3CA
Entrez ID5530
Gene full nameprotein phosphatase 3, catalytic subunit, alpha isozyme
Other gene symbolsCALN CALNA CALNA1 CCN1 CNA1 PPP2B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:0004721Phosphoprotein phosphatase activityIEAmolecular_function
GO:0004722Protein serine/threonine phosphatase activityNASmolecular_function
GO:0004723Calcium-dependent protein serine/threonine phosphatase activityIEAmolecular_function
GO:0005509Calcium ion bindingNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIDA IEA NASmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005955Calcineurin complexIEA NAScellular_component
GO:0006470Protein dephosphorylationIDA IEA NASbiological_process
GO:0006606Protein import into nucleusIEAbiological_process
GO:0006816Calcium ion transportIEAbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0014883Transition between fast and slow fiberIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016311DephosphorylationTASbiological_process
GO:0019899Enzyme bindingIDAmolecular_function
GO:0030018Z discIEAcellular_component
GO:0033173Calcineurin-NFAT signaling cascadeIEAbiological_process
GO:0033192Calmodulin-dependent protein phosphatase activityIDA TASmolecular_function
GO:0033555Multicellular organismal response to stressIEAbiological_process
GO:0035690Cellular response to drugIDAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046676Negative regulation of insulin secretionIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0046983Protein dimerization activityIPImolecular_function
GO:0048741Skeletal muscle fiber developmentIEAbiological_process
GO:0050804Regulation of synaptic transmissionIEAbiological_process
GO:0051592Response to calcium ionIDAbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30552906040.20057616730.99999024730.8660376148

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0597980707
GSE13712_SHEARDown-0.8217652487
GSE13712_STATICDown-0.6317881658
GSE19018Up0.5159347199
GSE19899_A1Up0.8115348992
GSE19899_A2Up0.0875961253
PubMed_21979375_A1Up0.2230651357
PubMed_21979375_A2Up0.1788418294
GSE35957Down-0.1795543389
GSE36640Down-0.2142438768
GSE54402Down-0.1812412422
GSE9593Down-0.2008307426
GSE43922Up0.2168438617
GSE24585Up0.2568833552
GSE37065Up0.2158886212
GSE28863_A1Up0.1582772635
GSE28863_A2Up0.1283877783
GSE28863_A3Down-0.0731740100
GSE28863_A4Down-0.2266748899
GSE48662Down-0.7967784704

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MYRISTIC ACIDDB08231 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT000677qRT-PCR//Luciferase reporter assay//Microarray//Reporter assay;OtherFunctional MTI19915607
hsa-miR-30a-5pMIMAT0000087MIRT005198pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-145-5pMIMAT0000437NAhsa-miR-14519915607
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.