HCSGD entry for VPS35
1. General information
| Official gene symbol | VPS35 |
|---|---|
| Entrez ID | 55737 |
| Gene full name | vacuolar protein sorting 35 homolog (S. cerevisiae) |
| Other gene symbols | MEM3 PARK17 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005768 | Endosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0042147 | Retrograde transport, endosome to Golgi | NAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7446967288 | 0.4685344478 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2545565782 |
| GSE13712_SHEAR | Down | -0.2086927973 |
| GSE13712_STATIC | Down | -0.2217639451 |
| GSE19018 | Up | 0.4051609059 |
| GSE19899_A1 | Down | -0.0157111675 |
| GSE19899_A2 | Down | -0.1090370454 |
| PubMed_21979375_A1 | Up | 0.1034176252 |
| PubMed_21979375_A2 | Down | -0.0823038462 |
| GSE35957 | Up | 0.0891249063 |
| GSE36640 | Down | -0.0349612842 |
| GSE54402 | Down | -0.0820693629 |
| GSE9593 | Up | 0.2102217036 |
| GSE43922 | Down | -0.0391531472 |
| GSE24585 | Down | -0.1197624985 |
| GSE37065 | Down | -0.0390464712 |
| GSE28863_A1 | Down | -0.0763697307 |
| GSE28863_A2 | Up | 0.0951856139 |
| GSE28863_A3 | Down | -0.3010782483 |
| GSE28863_A4 | Up | 0.1204653775 |
| GSE48662 | Down | -0.1686832396 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-590-3p | MIMAT0004801 | MIRT016199 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028711 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030421 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043692 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046485 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22142804 | METHODS: cGPx and CAT activities and H(2)O(2) levels were assayed in presenescent passage 5 and 10 cells, and in senescent passage 20, 25, 30 and 35 cells cultured in routine medium (MEM1) and supplemented media MEM2 and MEM3 containing normal and triple human plasma levels of Se, respectively |
| 22142804 | This activity underwent highly significant progressive increases in the same senescent cells subcultured in MEM3 |
| 22142804 | CONCLUSIONS: The highest cGPx activity and coupled lower H(2)O(2) generation were achieved in senescent cells cultured in MEM3 |
| 21538411 | SOD-1 and SOD-2 activities, however, underwent parallel progressive significant activity increases in senescent passage 20 and 25 cells, which peaked in value in passage 30 and 35 cells subcultured in supplemented medium (MEM3) containing triple human plasma levels of the cations |
| 21538411 | These rates, however, were significantly lowered in senescent cells subcultured in MEM3 |
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