HCSGD entry for PRKCE

1. General information

Official gene symbolPRKCE
Entrez ID5581
Gene full nameprotein kinase C, epsilon
Other gene symbolsPKCE nPKC-epsilon
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002281Macrophage activation involved in immune responseIEAbiological_process
GO:0003785Actin monomer bindingIEA ISSmolecular_function
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004697Protein kinase C activityIDAmolecular_function
GO:0004699Calcium-independent protein kinase C activityIEAmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005794Golgi apparatusIEA ISScellular_component
GO:0005829CytosolIDA IEA TAScellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008047Enzyme activator activityIMPmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0010634Positive regulation of epithelial cell migrationIMPbiological_process
GO:0010763Positive regulation of fibroblast migrationIEA ISSbiological_process
GO:0010811Positive regulation of cell-substrate adhesionIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0019899Enzyme bindingIPImolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0030546Receptor activator activityIEAmolecular_function
GO:0030838Positive regulation of actin filament polymerizationIEA ISSbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIEA ISSbiological_process
GO:0032024Positive regulation of insulin secretionIEAbiological_process
GO:0032230Positive regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0032467Positive regulation of cytokinesisIMPbiological_process
GO:0035276Ethanol bindingIEAmolecular_function
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0035641Locomotory exploration behaviorIEAbiological_process
GO:0035669TRAM-dependent toll-like receptor 4 signaling pathwayIEA ISSbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0043278Response to morphineIEAbiological_process
GO:0043410Positive regulation of MAPK cascadeIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEA ISScellular_component
GO:0050730Regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050996Positive regulation of lipid catabolic processIEAbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIEAbiological_process
GO:0051301Cell divisionIEAbiological_process
GO:0061178Regulation of insulin secretion involved in cellular response to glucose stimulusIEAbiological_process
GO:0070257Positive regulation of mucus secretionIEAbiological_process
GO:0071361Cellular response to ethanolIEAbiological_process
GO:0071456Cellular response to hypoxiaIEAbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
GO:0071944Cell peripheryIEA ISScellular_component
GO:0090303Positive regulation of wound healingIMPbiological_process
GO:2001031Positive regulation of cellular glucuronidationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41727862920.15554483870.99999024730.7621022520

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0203168840
GSE13712_SHEARUp0.8616200826
GSE13712_STATICUp0.3006534113
GSE19018Up0.0943401398
GSE19899_A1Down-0.2606055185
GSE19899_A2Down-0.3735637997
PubMed_21979375_A1Down-0.2093547125
PubMed_21979375_A2Down-0.1287094270
GSE35957Down-0.0306866667
GSE36640Up0.5159841684
GSE54402Down-0.6150837899
GSE9593Up0.0028788115
GSE43922Down-0.4960985792
GSE24585Down-0.5706771041
GSE37065Up0.2163815599
GSE28863_A1Up0.3833065136
GSE28863_A2Up0.3005213326
GSE28863_A3Down-0.0635832725
GSE28863_A4Down-0.0714955040
GSE48662Down-0.0253094741

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

KAI-1455DB06064 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-205-5pMIMAT0000266MIRT003667immunoblot//qRT-PCRFunctional MTI (Weak)19244118
hsa-miR-1MIMAT0000416MIRT007205Luciferase reporter assayFunctional MTI23226300
hsa-miR-31-5pMIMAT0000089MIRT007286Luciferase reporter assayFunctional MTI23364795
hsa-miR-96-5pMIMAT0000095MIRT027937SequencingFunctional MTI (Weak)20371350
hsa-miR-21-5pMIMAT0000076MIRT030913MicroarrayFunctional MTI (Weak)18591254
hsa-miR-342-3pMIMAT0000753MIRT043664CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-205-5pMIMAT0000266NAhsa-miR-205{Immunostaining}{overexpression by miRNA precursor transfection}19244118
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.