HCSGD entry for MAPK4

1. General information

Official gene symbolMAPK4
Entrez ID5596
Gene full namemitogen-activated protein kinase 4
Other gene symbolsERK-4 ERK3 Erk4 MAPK 4 PRKM4 p63MAPK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeTASbiological_process
GO:0004707MAP kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0019901Protein kinase bindingIEA ISSmolecular_function
GO:0023014Signal transduction by phosphorylationTASbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0042803Protein homodimerization activityIEA ISSmolecular_function
GO:0046982Protein heterodimerization activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82099154290.55921146230.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0259562976
GSE13712_SHEARUp0.0451533388
GSE13712_STATICDown-0.1273636687
GSE19018Up0.1256015163
GSE19899_A1Up0.0715792594
GSE19899_A2Down-0.0480591403
PubMed_21979375_A1Up0.0657337947
PubMed_21979375_A2Down-0.1774887929
GSE35957Up0.1090840033
GSE36640Up0.0338923807
GSE54402Up0.0493765109
GSE9593Down-0.0010959990
GSE43922Down-0.0749554111
GSE24585Down-0.5435542964
GSE37065Down-0.0981278169
GSE28863_A1Down-0.0673614870
GSE28863_A2Down-0.0305340891
GSE28863_A3Up0.2553035039
GSE28863_A4Up0.1005561846
GSE48662Up0.2148358403

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016876MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.