HCSGD entry for TMEM9B
1. General information
| Official gene symbol | TMEM9B |
|---|---|
| Entrez ID | 56674 |
| Gene full name | TMEM9 domain family, member B |
| Other gene symbols | C11orf15 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004871 | Signal transducer activity | IMP | molecular_function |
| GO:0007165 | Signal transduction | IMP | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0040621177 | 0.9978460963 | 0.1718954984 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6708376900 |
| GSE13712_SHEAR | Up | 0.0799312251 |
| GSE13712_STATIC | Up | 0.0886890070 |
| GSE19018 | Down | -0.1476716612 |
| GSE19899_A1 | Up | 0.2793851407 |
| GSE19899_A2 | Up | 0.4167373045 |
| PubMed_21979375_A1 | Up | 0.6572367078 |
| PubMed_21979375_A2 | Up | 0.5240027215 |
| GSE35957 | Up | 0.5859171072 |
| GSE36640 | Up | 1.4987867377 |
| GSE54402 | Up | 0.0235755494 |
| GSE9593 | Up | 0.6951304764 |
| GSE43922 | Up | 0.2970433619 |
| GSE24585 | Up | 0.2705533479 |
| GSE37065 | Up | 0.4045603006 |
| GSE28863_A1 | Up | 0.4989039100 |
| GSE28863_A2 | Up | 0.6232606632 |
| GSE28863_A3 | Down | -0.0411476534 |
| GSE28863_A4 | Up | 0.1633934555 |
| GSE48662 | Up | 0.1220635629 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT003846 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020217 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT021520 | Reporter assay;Microarray | Functional MTI | 21351259 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT026012 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031157 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-484 | MIMAT0002174 | MIRT041673 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042539 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21740549 | Comparison of these known targets with genes known to be up-regulated upon senescence in these cells, by micro-array expression profiling, identified 4 common genes TMEM9B, ATXN10, LAYN and LTBP2/3 |
| 21740549 | CONCLUSION: The senescence bypass screen identified TMEM9B, ATXN10, LAYN and LTBP2/3 as novel downstream effectors of the p53-p21 and p16-pRB tumour suppressor pathways |
| 21740549 | Although none of them has previously been linked to cellular senescence, TMEM9B has been suggested to be an upstream activator of NF-kappaB signalling which has been found to have a causal role in promoting senescence |
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