HCSGD entry for PSMC3

1. General information

Official gene symbolPSMC3
Entrez ID5702
Gene full nameproteasome (prosome, macropain) 26S subunit, ATPase, 3
Other gene symbolsTBP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0000932Cytoplasmic mRNA processing bodyIEA ISScellular_component
GO:0001824Blastocyst developmentIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006200ATP catabolic processISSbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016887ATPase activityISSmolecular_function
GO:0017111Nucleoside-triphosphatase activityIEAmolecular_function
GO:0022624Proteasome accessory complexIEA ISScellular_component
GO:0030163Protein catabolic processIEAbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:2001141Regulation of RNA biosynthetic processTASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89148170280.02915068960.99999024730.3237448523

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1977660660
GSE13712_SHEARUp0.0243776566
GSE13712_STATICDown-0.1196030327
GSE19018Down-0.5574247662
GSE19899_A1Down-0.9592895294
GSE19899_A2Down-0.3984697275
PubMed_21979375_A1Down-0.4042839371
PubMed_21979375_A2Down-1.9804609954
GSE35957Down-0.3414459041
GSE36640Down-0.8229141872
GSE54402Up0.2299440579
GSE9593Up0.0326279844
GSE43922Down-0.2644737425
GSE24585Down-0.0589187795
GSE37065Down-0.0961837005
GSE28863_A1Down-0.0998703300
GSE28863_A2Down-0.2197573507
GSE28863_A3Up0.3668355114
GSE28863_A4Up0.2277520729
GSE48662Down-0.1543162261

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-196a-5pMIMAT0000226MIRT048151CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049107CLASHFunctional MTI (Weak)23622248
hsa-miR-23a-3pMIMAT0000078MIRT050417CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.