HCSGD entry for TWSG1

1. General information

Official gene symbolTWSG1
Entrez ID57045
Gene full nametwisted gastrulation homolog 1 (Drosophila)
Other gene symbolsTSG
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0001707Mesoderm formationIEAbiological_process
GO:0005615Extracellular spaceIEAcellular_component
GO:0007435Salivary gland morphogenesisIEAbiological_process
GO:0030097HemopoiesisIEAbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIEAbiological_process
GO:0030900Forebrain developmentIEAbiological_process
GO:0043010Camera-type eye developmentIEAbiological_process
GO:0045668Negative regulation of osteoblast differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90342453170.01283647660.99999024730.2237542384

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5088725268
GSE13712_SHEARUp0.0244531724
GSE13712_STATICDown-0.1753446996
GSE19018Down-0.1763401932
GSE19899_A1Down-1.3853864019
GSE19899_A2Down-0.6735381822
PubMed_21979375_A1Down-1.4693385243
PubMed_21979375_A2Down-1.0464429517
GSE35957Up0.3992437062
GSE36640Up0.3204371238
GSE54402Down-1.0923744231
GSE9593Up0.4673708817
GSE43922Down-0.4764306660
GSE24585Down-0.0275085886
GSE37065Up0.1139214258
GSE28863_A1Up0.0544402356
GSE28863_A2Up0.1967183880
GSE28863_A3Down-0.4212519244
GSE28863_A4Up0.0794242416
GSE48662Down-0.0259106290

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022445MicroarrayFunctional MTI (Weak)18668037
hsa-miR-577MIMAT0003242MIRT040515CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17291568The gene p53 has been fashioned as the guardian of the genome and as prototype of the tumour suppressor gene (TSG) whose function must be inactivated in order for tumours to develop
17291568The evolutionary perspective indicates that p53 evolved so as to play a subtle but very important role during development while its role as a TSG is only important in animals that are protected from most sources of extrinsic mortality, thus suggesting that p53 was primarily selected for its developmental role and not as a TSG
10341711This appears to trigger growth inhibition via activation of the tumour suppressor gene (TSG) product, p53, and the consequent up-regulation of the cell-cycle inhibitor p21WAF1
10341711Other inhibitory pathways are also activated (possibly by additional clocks), including the TSG p16INK4a and the less well-defined complementation group genes
9436977Elevation of p16, the CDKN2/p16 tumor suppressor gene (TSG) product, occurs at senescence in normal human uroepithelial cells (HUC)
9436977Immortal HUCs and bladder cancer cell lines show either alteration of p16 or pRb, the product of the retinoblastoma (RB) TSG
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