HCSGD entry for AGTRAP
1. General information
| Official gene symbol | AGTRAP |
|---|---|
| Entrez ID | 57085 |
| Gene full name | angiotensin II receptor-associated protein |
| Other gene symbols | ATRAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0004945 | Angiotensin type II receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0008217 | Regulation of blood pressure | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030659 | Cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0106067969 | 0.9929908058 | 0.2615521536 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5102367021 |
| GSE13712_SHEAR | Up | 0.0239414635 |
| GSE13712_STATIC | Up | 0.1948731444 |
| GSE19018 | Up | 0.2639127405 |
| GSE19899_A1 | Up | 0.0804582701 |
| GSE19899_A2 | Up | 1.0860120041 |
| PubMed_21979375_A1 | Up | 0.7405098353 |
| PubMed_21979375_A2 | Up | 1.2005008564 |
| GSE35957 | Up | 0.0705506271 |
| GSE36640 | Up | 0.7170624323 |
| GSE54402 | Up | 0.1119863620 |
| GSE9593 | Up | 0.4267163350 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.4188811319 |
| GSE28863_A2 | Up | 0.4675233393 |
| GSE28863_A3 | Up | 0.0125908770 |
| GSE28863_A4 | Down | -0.3153125668 |
| GSE48662 | Up | 0.4442352667 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023506 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045764 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19769983 | We examined the possibility that ATRAP could attenuate AT(1) receptor-mediated vascular senescence via inactivation with the calcineurin/NFAT pathway |
| 19769983 | In contrast, VSMC prepared from ATRAP transgenic (ATRAP-Tg) mice exhibited attenuation of Ang-II-induced SA-beta-gal activity, oxidative stress, NFAT transcriptional activity, and expression of p53 and p21 |
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