HCSGD entry for PTPN11

1. General information

Official gene symbolPTPN11
Entrez ID5781
Gene full nameprotein tyrosine phosphatase, non-receptor type 11
Other gene symbolsBPTP3 CFC NS1 PTP-1D PTP2C SH-PTP2 SH-PTP3 SHP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000077DNA damage checkpointIEAbiological_process
GO:0000187Activation of MAPK activityIEAbiological_process
GO:0004721Phosphoprotein phosphatase activityIDAmolecular_function
GO:0004725Protein tyrosine phosphatase activityIDA TASmolecular_function
GO:0004726Non-membrane spanning protein tyrosine phosphatase activityIMP TASmolecular_function
GO:0005070SH3/SH2 adaptor activityIDAmolecular_function
GO:0005158Insulin receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006641Triglyceride metabolic processIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007420Brain developmentIMPbiological_process
GO:0007507Heart developmentIMPbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009755Hormone-mediated signaling pathwayIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030971Receptor tyrosine kinase bindingIEAmolecular_function
GO:0031295T cell costimulationTASbiological_process
GO:0031748D1 dopamine receptor bindingIEAmolecular_function
GO:0033628Regulation of cell adhesion mediated by integrinIMPbiological_process
GO:0035265Organ growthIEAbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationIDA IMPbiological_process
GO:0036302Atrioventricular canal developmentIMPbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038127ERBB signaling pathwayIDAbiological_process
GO:0040014Regulation of multicellular organism growthIEAbiological_process
GO:0042445Hormone metabolic processIEAbiological_process
GO:0042593Glucose homeostasisIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043274Phospholipase bindingIEAmolecular_function
GO:0043560Insulin receptor substrate bindingIEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0046676Negative regulation of insulin secretionIEAbiological_process
GO:0046825Regulation of protein export from nucleusIEAbiological_process
GO:0046887Positive regulation of hormone secretionIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048013Ephrin receptor signaling pathwayIDAbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048609Multicellular organismal reproductive processIEAbiological_process
GO:0048806Genitalia developmentIMPbiological_process
GO:0048839Inner ear developmentIMPbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051428Peptide hormone receptor bindingIEAmolecular_function
GO:0051463Negative regulation of cortisol secretionIEAbiological_process
GO:0060125Negative regulation of growth hormone secretionIEAbiological_process
GO:0060325Face morphogenesisIMPbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060338Regulation of type I interferon-mediated signaling pathwayTASbiological_process
GO:2001275Positive regulation of glucose import in response to insulin stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05356580300.81014486150.50534835131.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0267651031
GSE13712_SHEARUp0.1030536396
GSE13712_STATICUp0.0147912821
GSE19018Down-0.2025851822
GSE19899_A1Down-0.0499550713
GSE19899_A2Up0.0571228304
PubMed_21979375_A1Down-0.1155585082
PubMed_21979375_A2Down-0.3242426699
GSE35957Up0.4812581529
GSE36640Up0.1803552248
GSE54402Up0.1732924104
GSE9593Up0.3936875083
GSE43922Down-0.0053150529
GSE24585Down-0.2239125975
GSE37065Down-0.1929912679
GSE28863_A1Up0.8219538683
GSE28863_A2Up1.2345263211
GSE28863_A3Up0.4668827502
GSE28863_A4Up0.1356635849
GSE48662Up0.1397006815

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Dodecane-TrimethylamineDB02779 EXPT00833

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT006482Luciferase reporter assay//Western blotFunctional MTI17382377
hsa-miR-489-3pMIMAT0002805MIRT003549Luciferase reporter assay//Western blotFunctional MTI20700123
hsa-miR-23a-3pMIMAT0000078MIRT007150Luciferase reporter assayFunctional MTI23420868
hsa-miR-124-3pMIMAT0000422MIRT022573MicroarrayFunctional MTI (Weak)18668037
hsa-miR-218-5pMIMAT0000275MIRT024234SequencingFunctional MTI (Weak)20371350
hsa-miR-130b-5pMIMAT0004680MIRT038301CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041308CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044548CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047153CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23897841Impairment of Jak-Stat3 activation caused by GADD45G expression was associated with activation of SH2 domain-containing protein tyrosine phosphatase-2 (Shp2)
21934682An important downstream modulator of this signal cascade is SHP2 (Src homology domain-containing phosphatase 2)
21934682METHODS: We examined the The Cancer Genome Atlas (TCGA) database for SHP2 mutations
21934682We identified five siRNAs from two independent commercial sources that were reported by the vendor to be pre-optimised in their specificity of SHP2 silencing
21934682RESULTS: TCGA data demonstrate SHP2 to be mutated in 2% of the glioblastoma multiforme's studied
21934682We confirmed the biological significance by siRNA knockdown of SHP2
21934682All five siRNAs tested reduced SHP2 expression by 70-100% and reduced glioblastoma cell line growth by up to 80%
21934682Profiling the established molecular targets of SHP2 (ERK1/2 and STAT3) confirmed specificity of these siRNAs
21934682The loss of cell viability induced by SHP2 silencing could not be explained by a significant increase in apoptosis alone as demonstrated by terminal deoxyribonucleotidyl transferase-mediated nick-end labelling and propidium iodide staining
21934682Propidium iodide staining also showed that SHP2 silencing increases the population of glioblastoma cells in the G1 phase of the cell cycle and reduces the population of such cells in the G2/M- and S-phase
21934682Selective inhibitors of SHP2 are commercially available and may be considered as a strategy for glioblastoma therapy
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