HCSGD entry for RAB5C
1. General information
| Official gene symbol | RAB5C |
|---|---|
| Entrez ID | 5878 |
| Gene full name | RAB5C, member RAS oncogene family |
| Other gene symbols | L1880 RAB5CL RAB5L RABL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005811 | Lipid particle | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0007032 | Endosome organization | IEA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0030100 | Regulation of endocytosis | IEA | biological_process |
| GO:0030139 | Endocytic vesicle | IEA | cellular_component |
| GO:0031901 | Early endosome membrane | IEA | cellular_component |
| GO:0042470 | Melanosome | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0563445576 | 0.8980785343 | 0.5156624131 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4490725760 |
| GSE13712_SHEAR | Up | 0.0849134036 |
| GSE13712_STATIC | Up | 0.0907949365 |
| GSE19018 | Up | 0.0071338443 |
| GSE19899_A1 | Down | -0.1609335147 |
| GSE19899_A2 | Up | 0.8725405366 |
| PubMed_21979375_A1 | Up | 1.4604276920 |
| PubMed_21979375_A2 | Down | -0.3403559196 |
| GSE35957 | Down | -0.3187691408 |
| GSE36640 | Up | 0.3344286788 |
| GSE54402 | Up | 0.3794019213 |
| GSE9593 | Up | 0.3427719385 |
| GSE43922 | Up | 0.0487832533 |
| GSE24585 | Down | -0.0812398718 |
| GSE37065 | Up | 0.1092767791 |
| GSE28863_A1 | Down | -0.2372938767 |
| GSE28863_A2 | Up | 0.3449004285 |
| GSE28863_A3 | Up | 0.0943572016 |
| GSE28863_A4 | Up | 0.0309222892 |
| GSE48662 | Up | 0.1123486872 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001510 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016288 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045447 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046868 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048550 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12058077 | The model correctly predicts chromosome configurations (linear, Rabl, loop) and chromosome associations (homologous pairing, centromere and telomere clusters) on the basis of the geometrical constraints imposed by nuclear size and shape |
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