HCSGD entry for RASGRF1

1. General information

Official gene symbolRASGRF1
Entrez ID5923
Gene full nameRas protein-specific guanine nucleotide-releasing factor 1
Other gene symbolsCDC25 CDC25L GNRP GRF1 GRF55 H-GRF55 PP13187 ras-GRF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005085Guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005088Ras guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005829CytosolIEA ISScellular_component
GO:0005886Plasma membraneNAS TAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007616Long-term memoryNASbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0030426Growth coneIEA ISScellular_component
GO:0031175Neuron projection developmentIEA ISSbiological_process
GO:0032320Positive regulation of Ras GTPase activityISSbiological_process
GO:0032863Activation of Rac GTPase activityIEA ISSbiological_process
GO:0035020Regulation of Rac protein signal transductionIEA ISSbiological_process
GO:0035254Glutamate receptor bindingIEAmolecular_function
GO:0043005Neuron projectionNAScellular_component
GO:0046578Regulation of Ras protein signal transductionISSbiological_process
GO:0046579Positive regulation of Ras protein signal transductionISSbiological_process
GO:0048167Regulation of synaptic plasticityISSbiological_process
GO:0048168Regulation of neuronal synaptic plasticityIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45617622050.92749805860.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0753667532
GSE13712_SHEARUp0.1603039830
GSE13712_STATICUp0.1713128156
GSE19018Up0.1224633961
GSE19899_A1Down-0.0134490237
GSE19899_A2Up0.0411592566
PubMed_21979375_A1Up0.1167460079
PubMed_21979375_A2Up0.1817846167
GSE35957Up0.0787522274
GSE36640Up0.0098985354
GSE54402Up0.1422899494
GSE9593Up0.0177969502
GSE43922Up0.0258039830
GSE24585Up0.0190254510
GSE37065Down-0.0233251422
GSE28863_A1Down-0.1199786949
GSE28863_A2Down-0.0349703786
GSE28863_A3Up0.2359652248
GSE28863_A4Up0.2729261792
GSE48662Up0.0213321554

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029141MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.