HCSGD entry for RBP1


1. General information

Official gene symbolRBP1
Entrez ID5947
Gene full nameretinol binding protein 1, cellular
Other gene symbolsCRABP-I CRBP CRBP1 CRBPI RBPC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0005215Transporter activityIEAmolecular_function
GO:0005501Retinoid bindingTASmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006776Vitamin A metabolic processTASbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008289Lipid bindingIEAmolecular_function
GO:0016918Retinal bindingIEAmolecular_function
GO:0019841Retinol bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92861101780.00872206220.99999024730.1860506883

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6866357562
GSE13712_SHEARDown-1.6275527748
GSE13712_STATICDown-1.6098526989
GSE19018Down-0.6549375763
GSE19899_A1Up0.3001467259
GSE19899_A2Down-1.3116215636
PubMed_21979375_A1Up0.0756065931
PubMed_21979375_A2Down-1.0435537268
GSE35957Down-0.0680125388
GSE36640Down-1.9130244985
GSE54402Up0.2581285368
GSE9593Down-0.1285738771
GSE43922Up0.0428929823
GSE24585Up0.1360736434
GSE37065Down-0.0373978837
GSE28863_A1Down-0.1713489263
GSE28863_A2Up0.1276051616
GSE28863_A3Up0.1139693216
GSE28863_A4Up0.1114131292
GSE48662Down-0.4394339778

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL986CHEMBL20764P09455
CHEMBL7301CHEMBL20764P09455
CHEMBL418471CHEMBL20764P09455
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  • Drugs

Name

Drug

Accession number

Vitamin ADB00162 NUTR00007 | APRD00486

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018800MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18193082Both RBP1 and the highly related protein BCAA play a role in the induction of growth arrest and cellular senescence via mechanisms involving transcriptional repression
18193082While investigating the transcriptional repression activities of RBP1, we observed a genetic link between RBP1 and SIR2
18193082While investigating the transcriptional repression activities of RBP1, we observed a genetic link between RBP1 and SIR2
18193082Interestingly, the HDAC-dependent transcriptional repression domain of RBP1 proteins, termed R2, is necessary and sufficient for the interaction with SIRT1
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