HCSGD entry for RBP1
1. General information
Official gene symbol | RBP1 |
---|---|
Entrez ID | 5947 |
Gene full name | retinol binding protein 1, cellular |
Other gene symbols | CRABP-I CRBP CRBP1 CRBPI RBPC |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001523 | Retinoid metabolic process | TAS | biological_process |
GO:0005215 | Transporter activity | IEA | molecular_function |
GO:0005501 | Retinoid binding | TAS | molecular_function |
GO:0005829 | Cytosol | TAS | cellular_component |
GO:0006776 | Vitamin A metabolic process | TAS | biological_process |
GO:0007603 | Phototransduction, visible light | TAS | biological_process |
GO:0008289 | Lipid binding | IEA | molecular_function |
GO:0016918 | Retinal binding | IEA | molecular_function |
GO:0019841 | Retinol binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.9286110178 | 0.0087220622 | 0.9999902473 | 0.1860506883 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.6866357562 |
GSE13712_SHEAR | Down | -1.6275527748 |
GSE13712_STATIC | Down | -1.6098526989 |
GSE19018 | Down | -0.6549375763 |
GSE19899_A1 | Up | 0.3001467259 |
GSE19899_A2 | Down | -1.3116215636 |
PubMed_21979375_A1 | Up | 0.0756065931 |
PubMed_21979375_A2 | Down | -1.0435537268 |
GSE35957 | Down | -0.0680125388 |
GSE36640 | Down | -1.9130244985 |
GSE54402 | Up | 0.2581285368 |
GSE9593 | Down | -0.1285738771 |
GSE43922 | Up | 0.0428929823 |
GSE24585 | Up | 0.1360736434 |
GSE37065 | Down | -0.0373978837 |
GSE28863_A1 | Down | -0.1713489263 |
GSE28863_A2 | Up | 0.1276051616 |
GSE28863_A3 | Up | 0.1139693216 |
GSE28863_A4 | Up | 0.1114131292 |
GSE48662 | Down | -0.4394339778 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Compound | Target | Confidence score | Uniprot |
---|---|---|---|
CHEMBL986 | CHEMBL2076 | 4 | P09455 |
CHEMBL7301 | CHEMBL2076 | 4 | P09455 |
CHEMBL418471 | CHEMBL2076 | 4 | P09455 |
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- Drugs
Name | Drug | Accession number |
---|---|---|
Vitamin A | DB00162 | NUTR00007 | APRD00486 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-335-5p | MIMAT0000765 | MIRT018800 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
18193082 | Both RBP1 and the highly related protein BCAA play a role in the induction of growth arrest and cellular senescence via mechanisms involving transcriptional repression |
18193082 | While investigating the transcriptional repression activities of RBP1, we observed a genetic link between RBP1 and SIR2 |
18193082 | While investigating the transcriptional repression activities of RBP1, we observed a genetic link between RBP1 and SIR2 |
18193082 | Interestingly, the HDAC-dependent transcriptional repression domain of RBP1 proteins, termed R2, is necessary and sufficient for the interaction with SIRT1 |
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