HCSGD entry for RET

1. General information

Official gene symbolRET
Entrez ID5979
Gene full nameret proto-oncogene
Other gene symbolsCDHF12 CDHR16 HSCR1 MEN2A MEN2B MTC1 PTC RET-ELE1 RET51
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIEAbiological_process
GO:0001657Ureteric bud developmentIEAbiological_process
GO:0001755Neural crest cell migrationIEAbiological_process
GO:0001838Embryonic epithelial tube formationIEAbiological_process
GO:0004713Protein tyrosine kinase activityTASmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0004872Receptor activityTASmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0007156Homophilic cell adhesionIEAbiological_process
GO:0007158Neuron cell-cell adhesionIMPbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIEAbiological_process
GO:0007497Posterior midgut developmentTASbiological_process
GO:0010008Endosome membraneIDAcellular_component
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0014042Positive regulation of neuron maturationIEAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0030155Regulation of cell adhesionIDAbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0033619Membrane protein proteolysisIDAbiological_process
GO:0033630Positive regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0035799Ureter maturationIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042551Neuron maturationIEAbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0045121Membrane raftIEAcellular_component
GO:0045793Positive regulation of cell sizeIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0048265Response to painISSbiological_process
GO:0048484Enteric nervous system developmentIEAbiological_process
GO:0050770Regulation of axonogenesisIEAbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0060384InnervationIEAbiological_process
GO:0061146Peyer's patch morphogenesisISSbiological_process
GO:0071300Cellular response to retinoic acidIMPbiological_process
GO:0072300Positive regulation of metanephric glomerulus developmentISSbiological_process
GO:0097021Lymphocyte migration into lymphoid organsISSbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIMP TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13067825690.99178620490.73414988271.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1672645466
GSE13712_SHEARDown-0.0814120552
GSE13712_STATICDown-0.1222103818
GSE19018Up0.1051248438
GSE19899_A1Up0.2198235887
GSE19899_A2Up0.1658027236
PubMed_21979375_A1Up0.2996531208
PubMed_21979375_A2Up0.1943535480
GSE35957Up0.3150028327
GSE36640Up0.3338762776
GSE54402Up0.2362583494
GSE9593Up0.0841166874
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.0435402423

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SorafenibDB00398 APRD01304 | DB07438
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDB01809 EXPT02633
MP470DB05216 -
4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINEDB08764 -
CabozantinibDB08875 -
RegorafenibDB08896 -
PonatinibDB08901 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-31-5pMIMAT0000089MIRT004969Luciferase reporter assay//qRT-PCRNon-Functional MTI19524507
hsa-miR-29a-3pMIMAT0000086MIRT005908qRT-PCRFunctional MTI (Weak)21169019
hsa-miR-215-5pMIMAT0000272MIRT024374MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026714MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.