HCSGD entry for RNF2
1. General information
| Official gene symbol | RNF2 |
|---|---|
| Entrez ID | 6045 |
| Gene full name | ring finger protein 2 |
| Other gene symbols | BAP-1 BAP1 DING HIPI3 RING1B RING2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0000151 | Ubiquitin ligase complex | IDA | cellular_component |
| GO:0000278 | Mitotic cell cycle | IEA | biological_process |
| GO:0001702 | Gastrulation with mouth forming second | IEA | biological_process |
| GO:0001739 | Sex chromatin | IEA | cellular_component |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IDA IEA | molecular_function |
| GO:0009948 | Anterior/posterior axis specification | IEA | biological_process |
| GO:0016604 | Nuclear body | IEA | cellular_component |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0031519 | PcG protein complex | IDA | cellular_component |
| GO:0035102 | PRC1 complex | IDA | cellular_component |
| GO:0035518 | Histone H2A monoubiquitination | IDA | biological_process |
| GO:0036353 | Histone H2A-K119 monoubiquitination | ISS | biological_process |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
| GO:0071535 | RING-like zinc finger domain binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9503648494 | 0.0309747768 | 0.9999902473 | 0.3311875101 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3686600487 |
| GSE13712_SHEAR | Up | 0.0369865587 |
| GSE13712_STATIC | Up | 0.0568629608 |
| GSE19018 | Down | -0.7388332076 |
| GSE19899_A1 | Down | -0.2188289808 |
| GSE19899_A2 | Down | -0.4314755983 |
| PubMed_21979375_A1 | Up | 0.1182980250 |
| PubMed_21979375_A2 | Down | -0.6940864192 |
| GSE35957 | Down | -0.2009345118 |
| GSE36640 | Down | -0.6290823824 |
| GSE54402 | Up | 0.3131897124 |
| GSE9593 | Up | 0.0142588600 |
| GSE43922 | Down | -0.3686495262 |
| GSE24585 | Up | 0.5378112009 |
| GSE37065 | Up | 0.0073005417 |
| GSE28863_A1 | Down | -0.2818407095 |
| GSE28863_A2 | Down | -0.1347232047 |
| GSE28863_A3 | Down | -0.0853306471 |
| GSE28863_A4 | Down | -0.1147901972 |
| GSE48662 | Down | -0.2356624545 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT021040 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021180 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030193 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030624 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049365 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18076574 | Mel18-null MEFs undergo typical premature senescence accompanied by the up-regulation of ARF/p53/p16(INK4a) and decrease of Ring1b/Bmi1 |
| 18076574 | The in vivo binding of Ring1b and E2F3b to the ARF promoter decreased progressively in senescence, and Mel18 inactivation accelerated the exfoliation of Ring1b/E2F3b from the promoter sequence, indicating the cooperation of polycombs/E2F3b on ARF expression and cellular senescence |
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