HCSGD entry for ROBO1

1. General information

Official gene symbolROBO1
Entrez ID6091
Gene full nameroundabout, axon guidance receptor, homolog 1 (Drosophila)
Other gene symbolsDUTT1 SAX3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002042Cell migration involved in sprouting angiogenesisIMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007156Homophilic cell adhesionIDAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008046Axon guidance receptor activityTASmolecular_function
GO:0009986Cell surfaceIDAcellular_component
GO:0016199Axon midline choice point recognitionISSbiological_process
GO:0021836Chemorepulsion involved in postnatal olfactory bulb interneuron migrationIDAbiological_process
GO:0030275LRR domain bindingIPImolecular_function
GO:0030673AxolemmaIEAcellular_component
GO:0033600Negative regulation of mammary gland epithelial cell proliferationIMPbiological_process
GO:0035385Roundabout signaling pathwayIMPbiological_process
GO:0042802Identical protein bindingIDAmolecular_function
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0050772Positive regulation of axonogenesisIDAbiological_process
GO:0050925Negative regulation of negative chemotaxisIDAbiological_process
GO:0060763Mammary duct terminal end bud growthIEAbiological_process
GO:0070100Negative regulation of chemokine-mediated signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02234234260.72841093800.35731673741.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2858930200
GSE13712_SHEARDown-0.1948333237
GSE13712_STATICUp0.1858616392
GSE19018Down-0.3778329209
GSE19899_A1Up0.7549197530
GSE19899_A2Up0.0464990402
PubMed_21979375_A1Up0.5915322682
PubMed_21979375_A2Up0.3626816196
GSE35957Down-0.0195691423
GSE36640Up0.2977467881
GSE54402Down-0.1336418057
GSE9593Up0.8509435165
GSE43922Up0.6732373410
GSE24585Down-0.3248810791
GSE37065Up0.0431144832
GSE28863_A1Up0.4472865985
GSE28863_A2Up1.0286566636
GSE28863_A3Up0.0323784715
GSE28863_A4Down-0.2384835613
GSE48662Down-0.0106073262

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-217MIMAT0000274MIRT000481qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20300657
hsa-miR-423-3pMIMAT0001340MIRT042506CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050348CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-148b-3pMIMAT0000759NAhsa-miR-148b21205300
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.