HCSGD entry for NSD1
1. General information
| Official gene symbol | NSD1 |
|---|---|
| Entrez ID | 64324 |
| Gene full name | nuclear receptor binding SET domain protein 1 |
| Other gene symbols | ARA267 KMT3B SOTOS SOTOS1 STO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0001702 | Gastrulation with mouth forming second | IEA | biological_process |
| GO:0003682 | Chromatin binding | IEA ISS | molecular_function |
| GO:0003712 | Transcription cofactor activity | IDA IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | ISS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0010452 | Histone H3-K36 methylation | IDA ISS | biological_process |
| GO:0016571 | Histone methylation | ISS | biological_process |
| GO:0016922 | Ligand-dependent nuclear receptor binding | ISS | molecular_function |
| GO:0018022 | Peptidyl-lysine methylation | IDA ISS | biological_process |
| GO:0030331 | Estrogen receptor binding | ISS | molecular_function |
| GO:0034770 | Histone H4-K20 methylation | ISS | biological_process |
| GO:0034968 | Histone lysine methylation | IDA ISS | biological_process |
| GO:0042054 | Histone methyltransferase activity | IEA | molecular_function |
| GO:0042799 | Histone methyltransferase activity (H4-K20 specific) | ISS | molecular_function |
| GO:0042974 | Retinoic acid receptor binding | ISS | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0046965 | Retinoid X receptor binding | ISS | molecular_function |
| GO:0046966 | Thyroid hormone receptor binding | ISS | molecular_function |
| GO:0046975 | Histone methyltransferase activity (H3-K36 specific) | IDA ISS | molecular_function |
| GO:0050681 | Androgen receptor binding | IDA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3657718172 | 0.2231688462 | 0.9999902473 | 0.9088700603 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0504538542 |
| GSE13712_SHEAR | Up | 0.1701570635 |
| GSE13712_STATIC | Up | 0.3685156391 |
| GSE19018 | Down | -0.6848561860 |
| GSE19899_A1 | Down | -0.0160423209 |
| GSE19899_A2 | Up | 0.0300766979 |
| PubMed_21979375_A1 | Up | 0.2001261417 |
| PubMed_21979375_A2 | Down | -0.0842040580 |
| GSE35957 | Down | -0.1433104931 |
| GSE36640 | Down | -0.7364849671 |
| GSE54402 | Down | -0.2140062543 |
| GSE9593 | Down | -0.3804387136 |
| GSE43922 | Up | 0.0486597003 |
| GSE24585 | Down | -0.0552170295 |
| GSE37065 | Up | 0.0796149399 |
| GSE28863_A1 | Up | 1.2436726763 |
| GSE28863_A2 | Up | 0.7020375874 |
| GSE28863_A3 | Down | -0.2002412474 |
| GSE28863_A4 | Down | -0.1456983457 |
| GSE48662 | Down | -0.1124445938 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-423-5p | MIMAT0004748 | MIRT038162 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040128 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045301 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045467 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046367 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
