HCSGD entry for BMP2

1. General information

Official gene symbolBMP2
Entrez ID650
Gene full namebone morphogenetic protein 2
Other gene symbolsBDA2 BMP2A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000187Activation of MAPK activityIDAbiological_process
GO:0001501Skeletal system developmentTASbiological_process
GO:0001649Osteoblast differentiationIDAbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisISSbiological_process
GO:0001666Response to hypoxiaISSbiological_process
GO:0001701In utero embryonic developmentISSbiological_process
GO:0001837Epithelial to mesenchymal transitionIDAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0002062Chondrocyte differentiationIDAbiological_process
GO:0003130BMP signaling pathway involved in heart inductionIDAbiological_process
GO:0003181Atrioventricular valve morphogenesisISSbiological_process
GO:0003203Endocardial cushion morphogenesisISSbiological_process
GO:0003308Negative regulation of Wnt signaling pathway involved in heart developmentIDAbiological_process
GO:0004745Retinol dehydrogenase activityISSmolecular_function
GO:0005102Receptor bindingTASmolecular_function
GO:0005125Cytokine activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006029Proteoglycan metabolic processIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006954Inflammatory responseISSbiological_process
GO:0007219Notch signaling pathwayISSbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0009790Embryo developmentISSbiological_process
GO:0009887Organ morphogenesisISSbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDA IMPbiological_process
GO:0010894Negative regulation of steroid biosynthetic processIDAbiological_process
GO:0010922Positive regulation of phosphatase activityIDAbiological_process
GO:0019211Phosphatase activator activityIDAmolecular_function
GO:0021537Telencephalon developmentIDAbiological_process
GO:0021978Telencephalon regionalizationISSbiological_process
GO:0030177Positive regulation of Wnt signaling pathwayISSbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030282Bone mineralizationISSbiological_process
GO:0030335Positive regulation of cell migrationISSbiological_process
GO:0030501Positive regulation of bone mineralizationIDAbiological_process
GO:0030509BMP signaling pathwayIDA IEP IMP TASbiological_process
GO:0031648Protein destabilizationIEAbiological_process
GO:0032348Negative regulation of aldosterone biosynthetic processIDAbiological_process
GO:0033690Positive regulation of osteoblast proliferationISSbiological_process
GO:0035051Cardiocyte differentiationIDA IMPbiological_process
GO:0035054Embryonic heart tube anterior/posterior pattern specificationISSbiological_process
GO:0035630Bone mineralization involved in bone maturationIDAbiological_process
GO:0040007GrowthIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothISSbiological_process
GO:0042482Positive regulation of odontogenesisISSbiological_process
GO:0042487Regulation of odontogenesis of dentin-containing toothIEAbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0043569Negative regulation of insulin-like growth factor receptor signaling pathwayIDAbiological_process
GO:0045165Cell fate commitmentISSbiological_process
GO:0045600Positive regulation of fat cell differentiationISSbiological_process
GO:0045666Positive regulation of neuron differentiationISSbiological_process
GO:0045669Positive regulation of osteoblast differentiationIDAbiological_process
GO:0045778Positive regulation of ossificationIDAbiological_process
GO:0045786Negative regulation of cell cycleIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048711Positive regulation of astrocyte differentiationISSbiological_process
GO:0048762Mesenchymal cell differentiationIDAbiological_process
GO:0048839Inner ear developmentISSbiological_process
GO:0051042Negative regulation of calcium-independent cell-cell adhesionIDAbiological_process
GO:0055007Cardiac muscle cell differentiationIMPbiological_process
GO:0055008Cardiac muscle tissue morphogenesisISSbiological_process
GO:0055114Oxidation-reduction processISSbiological_process
GO:0060039Pericardium developmentISSbiological_process
GO:0060128Corticotropin hormone secreting cell differentiationISSbiological_process
GO:0060129Thyroid-stimulating hormone-secreting cell differentiationISSbiological_process
GO:0060317Cardiac epithelial to mesenchymal transitionIDAbiological_process
GO:0060389Pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0060485Mesenchyme developmentIMPbiological_process
GO:0060804Positive regulation of Wnt signaling pathway by BMP signaling pathwayISSbiological_process
GO:0061036Positive regulation of cartilage developmentIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDA IMPbiological_process
GO:0070700BMP receptor bindingIDAmolecular_function
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0071773Cellular response to BMP stimulusIDAbiological_process
GO:0072138Mesenchymal cell proliferation involved in ureteric bud developmentISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEPbiological_process
GO:1900745Positive regulation of p38MAPK cascadeIDAbiological_process
GO:1901522Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusIDAbiological_process
GO:2000065Negative regulation of cortisol biosynthetic processIDAbiological_process
GO:2000726Negative regulation of cardiac muscle cell differentiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00001154590.39344679910.01157777781.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.7464068481
GSE13712_SHEARDown-0.7558663102
GSE13712_STATICUp0.0468475493
GSE19018Down-0.4014416480
GSE19899_A1Up5.0703410211
GSE19899_A2Up7.2465205515
PubMed_21979375_A1Up8.0998842010
PubMed_21979375_A2Up9.2644710171
GSE35957Down-0.8445794944
GSE36640Up5.1888491781
GSE54402Up3.7114877187
GSE9593Down-2.1243131329
GSE43922Up3.4380475055
GSE24585Down-0.4739695013
GSE37065Up2.0876708521
GSE28863_A1Down-0.1763233739
GSE28863_A2Up0.5950145913
GSE28863_A3Up0.4281783195
GSE28863_A4Up0.0036993024
GSE48662Up0.0941460454

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017583MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT029250MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26981207Bmp2, a secreted protein to activate Bmp2-Smad signaling, was highly upregulated with gain of H3K4me3 and loss of H3K27me3 during Raf-induced senescence, as previously detected in Ras-induced senescence, and the knockdown of Bmp2 by shRNA lead to escape from Raf-induced senescence
26981207CONCLUSION: Although epigenetic alterations are partly different, Bmp2 upregulation and Smad6 repression occur and contribute to Raf-induced senescence, as detected in Ras-induced senescence
25342130Stimulation of endothelial cells (ECs) with TNF-alpha causes an increase in the expression of bone morphogenetic protein-2 (BMP-2) and the production of endothelial microparticles (EMPs)
25342130BMP-2 is known to produce osteogenic differentiation of vascular smooth muscle cells (VSMCs)
25342130It was found that EMPs from TNF-alpha-stimulated endothelial cells (HUVECs) contained a significant amount of BMP-2 and were able to enhance VSMC osteogenesis and calcification
25342130Inhibition of BMP-2 by small interfering RNA reduced the VSMC calcification induced by EMPs from TNF-alpha-treated HUVECs
25342130Similar osteogenic capability was observed in EMPs from both patients with chronic kidney disease and senescent cells, which also presented a high level of BMP-2 expression
25342130Our data suggest that EC damage results in the release of EMPs with a high content of calcium and BMP-2 that are able to induce calcification and osteogenic differentiation of VSMCs
24052948DNA damage in mammalian neural stem cells leads to astrocytic differentiation mediated by BMP2 signaling through JAK-STAT
24052948We demonstrate that BMP2 is necessary to induce expression of the astrocyte marker GFAP in irradiated NSCs via a noncanonical signaling pathway engaging JAK-STAT
22072987Bmp2 was the most activated secreted factor with H3K4me3 gain and H3K27me3 loss, whereas H3K4me3 loss and de novo formation of H3K27me3 occurred inversely in repression of nine genes, including two BMP-SMAD inhibitors Smad6 and Noggin
22072987Senescence was bypassed in Ras-activated cells when Bmp2/Smad1 signal was blocked by Bmp2 knockdown, Smad6 induction, or Noggin induction
22072987Senescence was induced when recombinant BMP2 protein was added to Bmp2-knocked-down Ras-activated cells
21324896Importantly, bone morphogenic protein 2 (BMP2) was able to intensify the differentiation of osteoblasts derived from WT MSCs, whereas this process was significantly impaired as a result of p85alpha deficiency
20647039Senescent VSMCs have been shown to overexpress genes and proteins (including RUNX-2, alkaline phosphatase (ALP), type I collagen and BMP-2) associated with osteoblasts, leading to partial osteoblastic transdifferentiation
19693768Fifteen cell-cycle regulator genes were investigated and only three genes (APC, CCND2, and BMP2) were differentially expressed between bMSC and oMSC
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