HCSGD entry for SLC1A1
1. General information
| Official gene symbol | SLC1A1 |
|---|---|
| Entrez ID | 6505 |
| Gene full name | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| Other gene symbols | EAAC1 EAAT3 SCZD18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003333 | Amino acid transmembrane transport | IDA | biological_process |
| GO:0005313 | L-glutamate transmembrane transporter activity | IDA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006811 | Ion transport | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0015501 | Glutamate:sodium symporter activity | IEA | molecular_function |
| GO:0016020 | Membrane | IEA TAS | cellular_component |
| GO:0016595 | Glutamate binding | IEA | molecular_function |
| GO:0017153 | Sodium:dicarboxylate symporter activity | IEA | molecular_function |
| GO:0034220 | Ion transmembrane transport | IDA | biological_process |
| GO:0051260 | Protein homooligomerization | IEA | biological_process |
| GO:0051938 | L-glutamate import | IDA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0070779 | D-aspartate import | IDA | biological_process |
| GO:1902475 | L-alpha-amino acid transmembrane transport | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0077284678 | 0.0235079670 | 0.2284627232 | 0.2956036772 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4386492467 |
| GSE13712_SHEAR | Down | -0.5713251016 |
| GSE13712_STATIC | Up | 0.0730437716 |
| GSE19018 | Up | 0.7212589580 |
| GSE19899_A1 | Down | -0.3042451057 |
| GSE19899_A2 | Down | -0.5977969453 |
| PubMed_21979375_A1 | Down | -0.0171205610 |
| PubMed_21979375_A2 | Down | -0.2515333413 |
| GSE35957 | Up | 1.1644911111 |
| GSE36640 | Up | 4.1176144980 |
| GSE54402 | Up | 0.0153103455 |
| GSE9593 | Up | 1.6585770376 |
| GSE43922 | Down | -0.8691555098 |
| GSE24585 | Down | -1.0570167354 |
| GSE37065 | Up | 0.4807788282 |
| GSE28863_A1 | Down | -0.5086069374 |
| GSE28863_A2 | Up | 0.9437174390 |
| GSE28863_A3 | Down | -1.1985441016 |
| GSE28863_A4 | Up | 0.3666830304 |
| GSE48662 | Down | -0.2371410214 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Aspartic Acid | DB00128 | NUTR00016 | EXPT01823 |
| L-Glutamic Acid | DB00142 | NUTR00027 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018599 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24706093 | Only EAAT3 was immunodetected in cultures and its total content was equal between them |
| 24706093 | PMA-stimulated EAAT3 trafficking to membrane increased 50% of L-[(3)H]glu-derived intracellular [(3)H] in EPC6 and had no effect in LPC6 |
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