HCSGD entry for WNK1
1. General information
| Official gene symbol | WNK1 |
|---|---|
| Entrez ID | 65125 |
| Gene full name | WNK lysine deficient protein kinase 1 |
| Other gene symbols | HSAN2 HSN2 KDP PRKWNK1 PSK p65 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003084 | Positive regulation of systemic arterial blood pressure | IEA | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0004860 | Protein kinase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006811 | Ion transport | ISS | biological_process |
| GO:0010923 | Negative regulation of phosphatase activity | IDA | biological_process |
| GO:0019902 | Phosphatase binding | IDA | molecular_function |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0048666 | Neuron development | NAS | biological_process |
| GO:0050794 | Regulation of cellular process | ISS | biological_process |
| GO:0090188 | Negative regulation of pancreatic juice secretion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0319908628 | 0.9913509783 | 0.4129272059 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0394490517 |
| GSE13712_SHEAR | Up | 0.0630573009 |
| GSE13712_STATIC | Up | 0.0106081285 |
| GSE19018 | Up | 0.1567890479 |
| GSE19899_A1 | Up | 0.1591490293 |
| GSE19899_A2 | Up | 0.3079835663 |
| PubMed_21979375_A1 | Up | 0.4340823462 |
| PubMed_21979375_A2 | Up | 0.7762599482 |
| GSE35957 | Up | 0.1395543889 |
| GSE36640 | Up | 0.3419662539 |
| GSE54402 | Up | 0.1839431960 |
| GSE9593 | Up | 0.1437549397 |
| GSE43922 | Up | 0.1049599075 |
| GSE24585 | Up | 0.0825336220 |
| GSE37065 | Up | 0.0507862140 |
| GSE28863_A1 | Up | 0.7508823566 |
| GSE28863_A2 | Up | 0.5304519192 |
| GSE28863_A3 | Up | 0.2628284347 |
| GSE28863_A4 | Up | 0.0896450596 |
| GSE48662 | Down | -0.0294972523 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT005582 | Luciferase reporter assay//Northern blot//qRT-PCR//Western blot | Functional MTI | 20813867 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT005583 | Luciferase reporter assay//Northern blot//qRT-PCR//Western blot | Functional MTI | 20813867 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030974 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037011 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-550a-5p | MIMAT0004800 | MIRT037785 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038570 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038785 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040135 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040788 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041474 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042524 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043274 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043954 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044712 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045005 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045660 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046056 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047108 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048089 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052359 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | 1 | hsa-miR-192 | {Western blot} | {downregulation by anti-miRNA} | 20813867 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
