HCSGD entry for SLC12A3
1. General information
| Official gene symbol | SLC12A3 |
|---|---|
| Entrez ID | 6559 |
| Gene full name | solute carrier family 12 (sodium/chloride transporters), member 3 |
| Other gene symbols | NCC NCCT TSC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005215 | Transporter activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006811 | Ion transport | TAS | biological_process |
| GO:0006814 | Sodium ion transport | ISS | biological_process |
| GO:0006820 | Anion transport | TAS | biological_process |
| GO:0006821 | Chloride transport | TAS | biological_process |
| GO:0015377 | Cation:chloride symporter activity | IEA | molecular_function |
| GO:0015378 | Sodium:chloride symporter activity | TAS | molecular_function |
| GO:0015698 | Inorganic anion transport | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IDA ISS | cellular_component |
| GO:0035725 | Sodium ion transmembrane transport | ISS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:1902476 | Chloride transmembrane transport | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8149925801 | 0.5704390145 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1113307872 |
| GSE13712_SHEAR | Down | -0.1766871958 |
| GSE13712_STATIC | Down | -0.1015410438 |
| GSE19018 | Down | -0.0322770978 |
| GSE19899_A1 | Down | -0.0276214575 |
| GSE19899_A2 | Down | -0.0522584628 |
| PubMed_21979375_A1 | Down | -0.1427880012 |
| PubMed_21979375_A2 | Down | -0.0382034671 |
| GSE35957 | Up | 0.0889704379 |
| GSE36640 | Up | 0.0164360173 |
| GSE54402 | Down | -0.0596641667 |
| GSE9593 | Down | -0.0760309217 |
| GSE43922 | Up | 0.0356394333 |
| GSE24585 | Down | -0.0030941130 |
| GSE37065 | Up | 0.0137507283 |
| GSE28863_A1 | Up | 0.0156627891 |
| GSE28863_A2 | Up | 0.1857206634 |
| GSE28863_A3 | Up | 0.4967209188 |
| GSE28863_A4 | Down | -0.0465854693 |
| GSE48662 | Down | -0.0562096262 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Bendroflumethiazide | DB00436 | APRD00666 |
| Chlorothiazide | DB00880 | APRD00721 |
| Hydrochlorothiazide | DB00999 | APRD00092 |
| Diazoxide | DB01119 | APRD00914 |
| Polythiazide | DB01324 | - |
| Quinethazone | DB01325 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017508 | Microarray | Functional MTI (Weak) | 18185580 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
