HCSGD entry for SLC12A4


1. General information

Official gene symbolSLC12A4
Entrez ID6560
Gene full namesolute carrier family 12 (potassium/chloride transporters), member 4
Other gene symbolsKCC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005765Lysosomal membraneIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006811Ion transportTASbiological_process
GO:0006813Potassium ion transportIEAbiological_process
GO:0006820Anion transportTASbiological_process
GO:0006821Chloride transportTASbiological_process
GO:0006884Cell volume homeostasisTASbiological_process
GO:0015379Potassium:chloride symporter activityIEAmolecular_function
GO:0015698Inorganic anion transportTASbiological_process
GO:0016020MembraneIEA TAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0055085Transmembrane transportIEA TASbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13088819190.94958501200.73481512051.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0333745266
GSE13712_SHEARUp0.0745543532
GSE13712_STATICUp0.0796066585
GSE19018Up0.0017572745
GSE19899_A1Down-0.0206783191
GSE19899_A2Up0.3162758463
PubMed_21979375_A1Up0.0039961873
PubMed_21979375_A2Up0.2363073952
GSE35957Up0.0669811290
GSE36640Up0.4020880428
GSE54402Down-0.1430572891
GSE9593Up0.1061753461
GSE43922Up0.4226687813
GSE24585Up0.4042548926
GSE37065Down-0.0628735281
GSE28863_A1Up0.0481629139
GSE28863_A2Up0.1271661871
GSE28863_A3Up0.0322846852
GSE28863_A4Down-0.0830240940
GSE48662Up0.7622023788

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Potassium ChlorideDB00761 APRD01322
BumetanideDB00887 APRD00294

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT005176pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-155-5pMIMAT0000646MIRT020815ProteomicsFunctional MTI (Weak)18668040
hsa-miR-92a-3pMIMAT0000092MIRT049408CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050324CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051485CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.