HCSGD entry for BMPR1A

1. General information

Official gene symbolBMPR1A
Entrez ID657
Gene full namebone morphogenetic protein receptor, type IA
Other gene symbols10q23del ACVRLK3 ALK3 CD292 SKR5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001707Mesoderm formationIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001880Mullerian duct regressionIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0003272Endocardial cushion formationISSbiological_process
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004675Transmembrane receptor protein serine/threonine kinase activityTASmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005901CaveolaIMPcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006955Immune responseIMPbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007398Ectoderm developmentIEAbiological_process
GO:0009950Dorsal/ventral axis specificationIEAbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0014032Neural crest cell developmentIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0019827Stem cell maintenanceIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0021998Neural plate mediolateral regionalizationIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0030501Positive regulation of bone mineralizationIMPbiological_process
GO:0030509BMP signaling pathwayIDA TASbiological_process
GO:0035137Hindlimb morphogenesisIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048352Paraxial mesoderm structural organizationIEAbiological_process
GO:0048368Lateral mesoderm developmentIEAbiological_process
GO:0048378Regulation of lateral mesodermal cell fate specificationIEAbiological_process
GO:0048382Mesendoderm developmentIEAbiological_process
GO:0048568Embryonic organ developmentIEAbiological_process
GO:0048589Developmental growthIEAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0050768Negative regulation of neurogenesisIEAbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060391Positive regulation of SMAD protein import into nucleusIDAbiological_process
GO:0060914Heart formationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95123574330.11904728920.99999024730.6623216445

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3274832970
GSE13712_SHEARUp0.0015970896
GSE13712_STATICUp0.0453041292
GSE19018Down-0.0930344598
GSE19899_A1Down-0.1896366797
GSE19899_A2Down-0.2218179647
PubMed_21979375_A1Down-0.3214853006
PubMed_21979375_A2Down-0.1770092314
GSE35957Up0.3379240947
GSE36640Up0.3136841603
GSE54402Down-0.2818251819
GSE9593Up0.0333383491
GSE43922Down-0.2900895280
GSE24585Down-0.1095144376
GSE37065Up0.1792218872
GSE28863_A1Up0.0944559519
GSE28863_A2Up0.0045291520
GSE28863_A3Down-0.4145344001
GSE28863_A4Down-0.0655513301
GSE48662Down-0.1978310892

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022438MicroarrayFunctional MTI (Weak)18668037
hsa-miR-455-3pMIMAT0004784MIRT037861CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26781745We have recently found that paired box gene 8 (Pax8) may be the downstream molecule of ALK3
26781745In H9C2 myogenic cells, Pax8 overexpression can rescue caspase-dependent apoptosis induced by ALK3 silencing
26781745These results suggest that Pax8 maybe the downstream molecule of ALK3, it mediates the murine heart development perhaps via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development
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