HCSGD entry for SNAI2

1. General information

Official gene symbolSNAI2
Entrez ID6591
Gene full namesnail family zinc finger 2
Other gene symbolsSLUG SLUGH1 SNAIL2 WS2D
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001649Osteoblast differentiationIEPbiological_process
GO:0001837Epithelial to mesenchymal transitionIMPbiological_process
GO:0003198Epithelial to mesenchymal transition involved in endocardial cushion formationISSbiological_process
GO:0003273Cell migration involved in endocardial cushion formationISSbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006933Negative regulation of cell adhesion involved in substrate-bound cell migrationIEAbiological_process
GO:0007219Notch signaling pathwayIMPbiological_process
GO:0007605Sensory perception of soundIMPbiological_process
GO:0009790Embryo developmentIEAbiological_process
GO:0010839Negative regulation of keratinocyte proliferationIDAbiological_process
GO:0010957Negative regulation of vitamin D biosynthetic processIDAbiological_process
GO:0014032Neural crest cell developmentIMPbiological_process
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0032331Negative regulation of chondrocyte differentiationIMPbiological_process
GO:0032642Regulation of chemokine productionIMPbiological_process
GO:0033629Negative regulation of cell adhesion mediated by integrinICbiological_process
GO:0035066Positive regulation of histone acetylationIEAbiological_process
GO:0035414Negative regulation of catenin import into nucleusIDAbiological_process
GO:0035921Desmosome disassemblyIMPbiological_process
GO:0043473PigmentationIMPbiological_process
GO:0043518Negative regulation of DNA damage response, signal transduction by p53 class mediatorIMPbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0044344Cellular response to fibroblast growth factor stimulusIEAbiological_process
GO:0045600Positive regulation of fat cell differentiationIEAbiological_process
GO:0045667Regulation of osteoblast differentiationIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050872White fat cell differentiationIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIMPbiological_process
GO:0060429Epithelium developmentISSbiological_process
GO:0060536Cartilage morphogenesisIEAbiological_process
GO:0060693Regulation of branching involved in salivary gland morphogenesisIEAbiological_process
GO:0070563Negative regulation of vitamin D receptor signaling pathwayIDAbiological_process
GO:0071364Cellular response to epidermal growth factor stimulusIDAbiological_process
GO:0071479Cellular response to ionizing radiationIEAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDA IMPbiological_process
GO:1900387Negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:1902230Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageIMPbiological_process
GO:2000647Negative regulation of stem cell proliferationIEAbiological_process
GO:2000810Regulation of tight junction assemblyIMPbiological_process
GO:2000811Negative regulation of anoikisIMPbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24974445500.02152378710.93875622500.2837565455

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0796986697
GSE13712_SHEARUp1.9127449001
GSE13712_STATICUp0.2627974753
GSE19018Up0.4730678993
GSE19899_A1Down-2.0232748304
GSE19899_A2Down-0.7633694693
PubMed_21979375_A1Down-1.2859740653
PubMed_21979375_A2Down-0.5624701577
GSE35957Up0.2863299309
GSE36640Down-0.4529500608
GSE54402Down-0.1624585837
GSE9593Up0.1703433974
GSE43922Down-0.5749765440
GSE24585Up1.2307833280
GSE37065Down-0.3090320263
GSE28863_A1Up0.0209780105
GSE28863_A2Down-0.2211773722
GSE28863_A3Up0.0334601798
GSE28863_A4Up0.0475605752
GSE48662Down-0.5546373224

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002716MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT002716Luciferase reporter assayFunctional MTI22253443
hsa-miR-124-3pMIMAT0000422MIRT002716Luciferase reporter assayFunctional MTI22262409
hsa-miR-124-3pMIMAT0000422MIRT002716Immunoblot//Immunofluorescence//Luciferase reporter assay//qRT-PCRFunctional MTI23250910
hsa-miR-124-3pMIMAT0000422MIRT002716MicroarrayFunctional MTI (Weak)18668037
hsa-miR-204-5pMIMAT0000265MIRT003273Luciferase reporter assayFunctional MTI20056717
hsa-miR-1MIMAT0000416MIRT007214Flow//Immunoblot//Immunofluorescence//Luciferase reporter assay//qRT-PCRFunctional MTI23142026
hsa-miR-182-5pMIMAT0000259MIRT007226Luciferase reporter assayFunctional MTI23354685
hsa-miR-203aMIMAT0000264MIRT007227Luciferase reporter assayFunctional MTI23354685
hsa-miR-545-3pMIMAT0003165MIRT007240Luciferase reporter assayFunctional MTI23434592
hsa-miR-630MIMAT0003299MIRT007241Luciferase reporter assayFunctional MTI23434592
hsa-miR-630MIMAT0003299MIRT007241Luciferase reporter assayFunctional MTI23435373
hsa-miR-148b-3pMIMAT0000759MIRT019445MicroarrayFunctional MTI (Weak)17612493
hsa-miR-9-5pMIMAT0000441MIRT021454MicroarrayFunctional MTI (Weak)17612493
hsa-miR-138-5pMIMAT0000430MIRT021687Western blot;qRT-PCRFunctional MTI21770894
hsa-miR-181a-5pMIMAT0000256MIRT025178MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24164458We found that IGFBP5 (insulin-like growth factor binding protein 5), PLAT (plasminogen activator), SNAI2 (snail homolog 2), JAG1 (jagged 1), SPRY4 (Sprouty homolog 4), and CD44 were upregulated, whereas CFB (complement factor B), VCAM1 (vascular cell adhesion molecule 1), AQP1 (aquaporin 1), LOXL1 (lysyl oxidase-like 1), and RBPMS (RNA-binding protein with multiple splicing) were down- regulated in both radiation-damaged and old cells
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