HCSGD entry for SP3
1. General information
| Official gene symbol | SP3 |
|---|---|
| Entrez ID | 6670 |
| Gene full name | Sp3 transcription factor |
| Other gene symbols | SPR2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IEA | molecular_function |
| GO:0000987 | Core promoter proximal region sequence-specific DNA binding | IEA | molecular_function |
| GO:0001078 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | IEA | molecular_function |
| GO:0001503 | Ossification | IEA | biological_process |
| GO:0001779 | Natural killer cell differentiation | IEA | biological_process |
| GO:0001829 | Trophectodermal cell differentiation | IEA | biological_process |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0001892 | Embryonic placenta development | IEA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003690 | Double-stranded DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IC | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0017053 | Transcriptional repressor complex | IEA | cellular_component |
| GO:0030183 | B cell differentiation | IEA | biological_process |
| GO:0030217 | T cell differentiation | IEA | biological_process |
| GO:0030219 | Megakaryocyte differentiation | IEA | biological_process |
| GO:0030224 | Monocyte differentiation | IEA | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0030851 | Granulocyte differentiation | IEA | biological_process |
| GO:0043353 | Enucleate erythrocyte differentiation | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP NAS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA NAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048596 | Embryonic camera-type eye morphogenesis | IEA | biological_process |
| GO:0048706 | Embryonic skeletal system development | IEA | biological_process |
| GO:0060136 | Embryonic process involved in female pregnancy | IEA | biological_process |
| GO:0060216 | Definitive hemopoiesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8180353976 | 0.3377423464 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0408916125 |
| GSE13712_SHEAR | Down | -0.0042691594 |
| GSE13712_STATIC | Down | -0.0801881154 |
| GSE19018 | Up | 0.0846359692 |
| GSE19899_A1 | Down | -0.0724444950 |
| GSE19899_A2 | Down | -0.1696040923 |
| PubMed_21979375_A1 | Up | 0.2003582672 |
| PubMed_21979375_A2 | Down | -0.0363162210 |
| GSE35957 | Down | -0.0158515176 |
| GSE36640 | Down | -0.8904566394 |
| GSE54402 | Up | 0.2859214448 |
| GSE9593 | Down | -0.1820598277 |
| GSE43922 | Down | -0.0289188152 |
| GSE24585 | Up | 0.3655739419 |
| GSE37065 | Up | 0.1890015690 |
| GSE28863_A1 | Up | 0.1403911922 |
| GSE28863_A2 | Up | 0.1990827137 |
| GSE28863_A3 | Down | -0.3516330241 |
| GSE28863_A4 | Down | -0.1581269472 |
| GSE48662 | Down | -0.3516386996 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-27a-3p | MIMAT0000084 | MIRT002402 | Western blot | Functional MTI | 18006846 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT002402 | Western blot;qRT-PCR | Functional MTI | 20382698 |
| hsa-miR-223-3p | MIMAT0000280 | MIRT006249 | Luciferase reporter assay//Western blot | Functional MTI | 22080513 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022933 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-484 | MIMAT0002174 | MIRT042140 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052769 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
