HCSGD entry for SRD5A2

1. General information

Official gene symbolSRD5A2
Entrez ID6716
Gene full namesteroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00038653-oxo-5-alpha-steroid 4-dehydrogenase activityIEAmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006702Androgen biosynthetic processTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008209Androgen metabolic processIDAbiological_process
GO:0008584Male gonad developmentIMPbiological_process
GO:0009917Sterol 5-alpha reductase activityIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030154Cell differentiationIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047751Cholestenone 5-alpha-reductase activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30677617110.93602346800.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0745917810
GSE13712_SHEARUp0.0708099808
GSE13712_STATICDown-0.1096066520
GSE19018Down-0.1560067918
GSE19899_A1Down-0.0615274737
GSE19899_A2Up0.0409685002
PubMed_21979375_A1Up0.0649738190
PubMed_21979375_A2Up0.0279548833
GSE35957Up0.0663838928
GSE36640Up0.2363108241
GSE54402Up0.0045173157
GSE9593Up0.1285008820
GSE43922Up0.0342842564
GSE24585Down-0.0038302725
GSE37065Down-0.0746532137
GSE28863_A1Up0.5961158594
GSE28863_A2Up0.4057337388
GSE28863_A3Up0.1390475650
GSE28863_A4Up0.1230919506
GSE48662Up0.1677037341

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DutasterideDB01126 APRD00385
FinasterideDB01216 APRD00632 | DB07774
SpironolactoneDB00421 APRD01234

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.