HCSGD entry for SREBF1

1. General information

Official gene symbolSREBF1
Entrez ID6720
Gene full namesterol regulatory element binding transcription factor 1
Other gene symbolsSREBP-1c SREBP1 bHLHd1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0003062Regulation of heart rate by chemical signalIEAbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005635Nuclear envelopeTAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006629Lipid metabolic processTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0008286Insulin receptor signaling pathwayIEAbiological_process
GO:0008610Lipid biosynthetic processIEA ISSbiological_process
GO:0009267Cellular response to starvationIEA ISSbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0010867Positive regulation of triglyceride biosynthetic processIEA ISSbiological_process
GO:0012507ER to Golgi transport vesicle membraneIEAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019217Regulation of fatty acid metabolic processIEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030324Lung developmentIEAbiological_process
GO:0031065Positive regulation of histone deacetylationIEAbiological_process
GO:0032094Response to foodIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032526Response to retinoic acidIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0032810Sterol response element bindingIDAmolecular_function
GO:0033762Response to glucagonIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045542Positive regulation of cholesterol biosynthetic processIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0046676Negative regulation of insulin secretionIEAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0051591Response to cAMPIEAbiological_process
GO:0071398Cellular response to fatty acidIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18301072150.83467424110.83667754431.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0040891996
GSE13712_SHEARUp0.4024354004
GSE13712_STATICUp0.6054010180
GSE19018Up0.1417528357
GSE19899_A1Down-0.0073789191
GSE19899_A2Down-0.0421090765
PubMed_21979375_A1Down-0.2231221379
PubMed_21979375_A2Up0.4251065760
GSE35957Down-0.1425918871
GSE36640Down-0.0711082548
GSE54402Up0.1216627847
GSE9593Up0.0712606062
GSE43922Down-0.2129422318
GSE24585Up0.1621680772
GSE37065Down-0.1202770797
GSE28863_A1Up0.3710470925
GSE28863_A2Up0.1659598029
GSE28863_A3Up0.2204911423
GSE28863_A4Down-0.0434512159
GSE48662Up0.1541303218

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018325MicroarrayFunctional MTI (Weak)18185580
hsa-miR-744-5pMIMAT0004945MIRT037474CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038739CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041670CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-3pMIMAT0000732MIRT043859CLASHFunctional MTI (Weak)23622248
hsa-miR-185-5pMIMAT0000455MIRT045315CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047574CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050226CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051418CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24398515A series of experiments that used siRNAs indicated that LXRbeta mediates the prevention of endothelial cellular senescence, and that sterol regulatory element binding protein-1, which was up-regulated as a direct LXRbeta target gene, may act as a brake of endothelial cellular senescence
24396695BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an increase in organellar mass, one of the indicators of senescence
24396695RESULTS: In this model of stress-induced cell senescence using DFO and H2O2, the phosphorylation profile of glycogen synthase kinase 3alpha (GSK3alpha) and beta corresponded closely to the expression profile of the mature form of SREBP-1 protein
24396695Inhibition of GSK3 with a subcytotoxic concentration of the selective GSK3 inhibitor SB415286 significantly increased mature SREBP1 expression, as well as lipogenesis and organellar mass
24396695Suppression of GSK3 expression with siRNAs specific to GSK3alpha and beta also increased mature SREBP1 expression and induced senescence
24396695Finally, blocking lipogenesis with fatty acid synthase inhibitors (cerulenin and C75) and siRNA-mediated silencing of SREBP1 and ATP citrate lyase (ACL) significantly attenuated GSK3 inhibition-induced senescence
20649541Anabolism was accomplished through glycogen synthase, eIF2B, and SREBP1
20615871The mature form of sterol regulatory element-binding protein (SREBP)-1 was also elevated
20615871Ectopic expression of mature form of SREBP-1 in both Chang cells and primary young human diploid fibroblasts was enough to induce senescence
20615871Our results suggest that enhanced lipogenesis is not only a common event, but also critically involved in senescence via SREBP-1 induction, thereby contributing to the increase in organelle mass (as a part of cell mass), a novel indicator of senescence
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