HCSGD entry for SRF
1. General information
| Official gene symbol | SRF |
|---|---|
| Entrez ID | 6722 |
| Gene full name | serum response factor (c-fos serum response element-binding transcription factor) |
| Other gene symbols | MCM1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IEA | cellular_component |
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA ISS | molecular_function |
| GO:0000983 | RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity | IMP | molecular_function |
| GO:0001076 | RNA polymerase II transcription factor binding transcription factor activity | IEA | molecular_function |
| GO:0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | IDA IEA | molecular_function |
| GO:0001228 | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | ISS | molecular_function |
| GO:0001569 | Patterning of blood vessels | IEA | biological_process |
| GO:0001666 | Response to hypoxia | IEP | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001707 | Mesoderm formation | IEA | biological_process |
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0001829 | Trophectodermal cell differentiation | IDA | biological_process |
| GO:0001947 | Heart looping | IEA ISS | biological_process |
| GO:0002011 | Morphogenesis of an epithelial sheet | IEA | biological_process |
| GO:0002042 | Cell migration involved in sprouting angiogenesis | IEA IMP | biological_process |
| GO:0003257 | Positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation | IEA IGI | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA TAS | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0007160 | Cell-matrix adhesion | IEA | biological_process |
| GO:0007507 | Heart development | ISS | biological_process |
| GO:0007616 | Long-term memory | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0008306 | Associative learning | IEA | biological_process |
| GO:0009636 | Response to toxic substance | TAS | biological_process |
| GO:0009725 | Response to hormone | IDA | biological_process |
| GO:0010669 | Epithelial structure maintenance | IEA | biological_process |
| GO:0010735 | Positive regulation of transcription via serum response element binding | IDA | biological_process |
| GO:0010736 | Serum response element binding | IDA IEA | molecular_function |
| GO:0021766 | Hippocampus development | IEA | biological_process |
| GO:0022028 | Tangential migration from the subventricular zone to the olfactory bulb | IEA | biological_process |
| GO:0030038 | Contractile actin filament bundle assembly | IEA | biological_process |
| GO:0030155 | Regulation of cell adhesion | IEA | biological_process |
| GO:0030168 | Platelet activation | IEA | biological_process |
| GO:0030220 | Platelet formation | IEA | biological_process |
| GO:0030336 | Negative regulation of cell migration | IEA | biological_process |
| GO:0031175 | Neuron projection development | IEA | biological_process |
| GO:0031490 | Chromatin DNA binding | IEA | molecular_function |
| GO:0033561 | Regulation of water loss via skin | IEA | biological_process |
| GO:0034097 | Response to cytokine | IMP NAS | biological_process |
| GO:0035855 | Megakaryocyte development | IEA | biological_process |
| GO:0035912 | Dorsal aorta morphogenesis | IEA | biological_process |
| GO:0042789 | MRNA transcription from RNA polymerase II promoter | IEA ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043149 | Stress fiber assembly | IEA | biological_process |
| GO:0043589 | Skin morphogenesis | IEA | biological_process |
| GO:0045059 | Positive thymic T cell selection | IEA | biological_process |
| GO:0045214 | Sarcomere organization | IEA | biological_process |
| GO:0045597 | Positive regulation of cell differentiation | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0045987 | Positive regulation of smooth muscle contraction | IDA | biological_process |
| GO:0046016 | Positive regulation of transcription by glucose | IEA | biological_process |
| GO:0046716 | Muscle cell cellular homeostasis | IEA ISS | biological_process |
| GO:0048589 | Developmental growth | IEA | biological_process |
| GO:0048666 | Neuron development | TAS | biological_process |
| GO:0048821 | Erythrocyte development | IEA | biological_process |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0051150 | Regulation of smooth muscle cell differentiation | TAS | biological_process |
| GO:0051491 | Positive regulation of filopodium assembly | IEA | biological_process |
| GO:0055003 | Cardiac myofibril assembly | IEA | biological_process |
| GO:0060055 | Angiogenesis involved in wound healing | TAS | biological_process |
| GO:0060218 | Hematopoietic stem cell differentiation | IEA | biological_process |
| GO:0060261 | Positive regulation of transcription initiation from RNA polymerase II promoter | IDA | biological_process |
| GO:0060292 | Long term synaptic depression | IEA | biological_process |
| GO:0060347 | Heart trabecula formation | IEA | biological_process |
| GO:0060947 | Cardiac vascular smooth muscle cell differentiation | IEA | biological_process |
| GO:0061029 | Eyelid development in camera-type eye | IEA | biological_process |
| GO:0070830 | Tight junction assembly | IEA | biological_process |
| GO:0071333 | Cellular response to glucose stimulus | IEA | biological_process |
| GO:0090009 | Primitive streak formation | IEA | biological_process |
| GO:0090136 | Epithelial cell-cell adhesion | IEA | biological_process |
| GO:0090398 | Cellular senescence | IMP | biological_process |
| GO:1900222 | Negative regulation of beta-amyloid clearance | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9369304396 | 0.0264389081 | 0.9999902473 | 0.3115033572 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7398194475 |
| GSE13712_SHEAR | Down | -0.0016098630 |
| GSE13712_STATIC | Down | -0.1314120727 |
| GSE19018 | Down | -0.7414630595 |
| GSE19899_A1 | Down | -0.2605198497 |
| GSE19899_A2 | Down | -0.0911908289 |
| PubMed_21979375_A1 | Down | -0.2595787547 |
| PubMed_21979375_A2 | Up | 0.0591350008 |
| GSE35957 | Up | 0.3143434686 |
| GSE36640 | Down | -0.2868436367 |
| GSE54402 | Up | 0.1293133816 |
| GSE9593 | Down | -0.1652813796 |
| GSE43922 | Up | 0.0381025633 |
| GSE24585 | Down | -0.6458941173 |
| GSE37065 | Down | -0.1897235460 |
| GSE28863_A1 | Down | -0.0156834304 |
| GSE28863_A2 | Down | -0.1428923871 |
| GSE28863_A3 | Up | 0.4879642637 |
| GSE28863_A4 | Down | -0.2570515151 |
| GSE48662 | Down | -0.2197027803 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT000365 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19726678 |
| hsa-miR-1 | MIMAT0000416 | MIRT023547 | Western blot | Non-Functional MTI | 20458751 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028897 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040918 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041943 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042926 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043424 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044832 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049829 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 12 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25183317 | BACKGROUND: The protein p49/STRAP (SRFBP1) is a transcription cofactor of serum response factor (SRF) which regulates cytoskeletal and muscle-specific genes |
| 25183317 | CONCLUSIONS: Since p49/STRAP is a co-factor of SRF, our data suggest that p49/STRAP likely regulates cell size and morphology through SRF target genes |
| 22467316 | Serum response factor and miRNA expression represent main mechanisms controlling the pattern of gene expression |
| 21160097 | There are also MCM1 and MCM10, which are important in DNA replication, but they do not possess the specific MCM box |
| 16786104 | We observed the changes of these three kinds of HUVECs (HUVECs, N17Rac1-HUVECs, V12Rac1-HUVECs) after hypoxia for 48 h and 96 h, the expression and localization of serum response factor (SRF), which is one of the downstream signal molecules of Rac1, were also investigated |
| 16786104 | To further investigate the mechanism of HUVEC senescence induced by Rac1, we detected the expression of total SRF (tSRF) and nuclear SRF (nSRF) in these three kinds of HUVECs by immunofluorescent analysis and Western blot assay after hypoxia |
| 16786104 | The results showed that the expression of nSRF decreased obviously and the nuclear translocation of SRF was inhibited in HUVECs infected by V12Rac1 compared with those in the normal HUVECs |
| 16786104 | These results suggest that activation of Rac1 accelerates endothelial cell senescence and inhibition of Rac1 activity prevents HUVECs from entering senescence induced by hypoxia, while the nuclear translocation of SRF regulated by Rac1 might play an important role in the process of senescence |
| 15282327 | Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor |
| 15282327 | The serum response factor (SRF), a major transcriptional activator of immediate-early gene promoters, loses the ability to bind to the serum response element (SRE) and becomes hyperphosphorylated in senescent cells |
| 15282327 | We identify protein kinase C delta (PKC delta) as the kinase responsible for inactivation of SRF both in vitro and endogenously in senescent cells |
| 15282327 | The phosphorylation of T160 of SRF by PKC delta in vitro and in vivo led to loss of SRF DNA binding activity |
| 12470826 | Transcription of c-fos in response to mitogens depends on the activation of a multiprotein complex formed on the c-fos serum response element (SRE), which includes the transcription factors serum response factor (SRF) and ternary complex factor (TCF) |
| 11570821 | Transcription of c-fos in response to mitogens depends on the activation of a multiprotein complex formed on the c-fos serum response element (SRE), which includes the transcription factors SRF (serum response factor) and TCF (ternary complex factor) |
| 11570821 | These impairments, together with the impaired DNA binding activity of SRF, could potentially account for the lack of c-fos expression in senescent cells and for multiple other molecular changes dependent upon this pathway |
| 11181183 | Senescence represses the nuclear localization of the serum response factor and differentiation regulates its nuclear localization with lineage specificity |
| 11181183 | The differentiation of cultured 3T3T mesenchymal stem cells into adipocytes represses growth factor responsiveness by limiting the nuclear localization of the serum response factor (SRF) that binds to and activates the promoters of growth control genes that contain the serum response elements (SRE), such as junB and c-fos |
| 11181183 | The regulation of SRF nuclear localization by adipocyte differentiation is specific, because we show that adipocyte differentiation does not repress the nuclear localization of six other transacting factors |
| 11181183 | To determine if repression of growth factor responsiveness that occurs during senescence also represses the nuclear localization of SRF, we studied normal human WI-38 fibroblasts at low versus high population doublings |
| 11181183 | The results show that SRF localizes to the nucleus of proliferative cells whereas in senescent cells SRF can not be detected in the nucleus |
| 11181183 | We next evaluated the cellular distribution of SRF in selected human tissues to determine whether the loss of proliferative potential in vivo could have a different effect on SRF nuclear localization |
| 11181183 | We found that in cells of the small bowel mucosa, differentiation modulates SRF nuclear localization in an opposite manner |
| 11181183 | Minimal SRF expression and nuclear localization is evident in undifferentiated cells at the base of crypts whereas increased SRF expression and nuclear localization is evident in differentiated cells at the surface tip of the villus |
| 11181183 | These results together establish that regulation of SRF expression and nuclear localization is important in senescence and differentiation in a lineage specific manner |
| 10082129 | Electrophoretic mobility shift studies using young and old cell nuclear extracts showed a marked decrease in serum response factor (SRF) binding activity to the SRE in old compared to young cells |
| 10082129 | Loss of SRF binding activity has been correlated with the loss of expression of another growth-related immediate-early gene (c-fos) |
| 8864058 | Here we survey the relevant literature regarding altered gene expression and the role of transcription factors during cellular aging, focusing upon the serum response factor (SRF) |
| 8864058 | SRF is hyperphosphorylated in senescent HDFs and fails to bind to the serum-response element in the c-fos promoter |
| 8864058 | Differential phosphorylation during replicative aging may contribute, at least in part, to the altered activity of SRF and possibly other transcription factors and to subsequent changes in the expression of serum-regulated genes in senescent HDFs |
| 8960358 | We focus on regulation of the c-fos gene through posttranslational modification of the serum response factor (SRF) as an example of altered gene expression during cellular aging |
| 8007992 | While no major differences in the expression of the serum response factor (SRF) that binds the serum response element were seen between early-passage and late-passage cells, hyperphosphorylation of SRF was observed in near-senescent cells |
| 8007992 | Furthermore, removal of phosphatase inhibitors during the isolation of endogenous nuclear proteins restored the ability of SRF isolated from old cells to bind the SRE |
| 8007992 | These data, therefore, indicate that hyperphosphorylation of SRF plays a role in altering the ability of this protein to bind to DNA and regulate gene expression in senescent cells |
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