HCSGD entry for BRCA2

1. General information

Official gene symbolBRCA2
Entrez ID675
Gene full namebreast cancer 2, early onset
Other gene symbolsBRCC2 BROVCA2 FACD FAD FAD1 FANCB FANCD FANCD1 GLM3 PNCA2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000724Double-strand break repair via homologous recombinationIDA IEA TASbiological_process
GO:0000910CytokinesisIDAbiological_process
GO:0001556Oocyte maturationIEAbiological_process
GO:0001833Inner cell mass cell proliferationIEAbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0003697Single-stranded DNA bindingIDAmolecular_function
GO:0004402Histone acetyltransferase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006289Nucleotide-excision repairIMPbiological_process
GO:0006302Double-strand break repairIMP TASbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIEAbiological_process
GO:0007141Male meiosis IIEAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007569Cell agingIEAbiological_process
GO:0008585Female gonad developmentIEAbiological_process
GO:0010165Response to X-rayIEAbiological_process
GO:0010225Response to UV-CIEAbiological_process
GO:0010332Response to gamma radiationIEAbiological_process
GO:0010484H3 histone acetyltransferase activityIDAmolecular_function
GO:0010485H4 histone acetyltransferase activityIDAmolecular_function
GO:0030097HemopoiesisIEAbiological_process
GO:0030141Secretory granuleIDAcellular_component
GO:0032465Regulation of cytokinesisIEAbiological_process
GO:0033593BRCA2-MAGE-D1 complexIDAcellular_component
GO:0033600Negative regulation of mammary gland epithelial cell proliferationIDAbiological_process
GO:0042771Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIEAbiological_process
GO:0043015Gamma-tubulin bindingIPImolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043966Histone H3 acetylationIDAbiological_process
GO:0043967Histone H4 acetylationIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045931Positive regulation of mitotic cell cycleIEAbiological_process
GO:0048478Replication fork protectionIEAbiological_process
GO:0051276Chromosome organizationIEAbiological_process
GO:0051298Centrosome duplicationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96662856650.00108422930.99999024730.0626905908

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2005867215
GSE13712_SHEARUp0.0162402633
GSE13712_STATICDown-0.4343807164
GSE19018Up0.0334344941
GSE19899_A1Down-0.5064931657
GSE19899_A2Down-3.8052187485
PubMed_21979375_A1Down-1.4926101897
PubMed_21979375_A2Down-1.9337619543
GSE35957Down-1.9311961942
GSE36640Down-3.5921781401
GSE54402Down-0.1624200587
GSE9593Down-0.6592995414
GSE43922Down-1.4527685813
GSE24585Down-0.0583373848
GSE37065Up0.0595746057
GSE28863_A1Down-0.1758597120
GSE28863_A2Up0.6292163817
GSE28863_A3Down-0.2041023510
GSE28863_A4Up0.1362091880
GSE48662Down-0.2168646984

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1245aMIMAT0005897MIRT006574Luciferase reporter assay//Western blotFunctional MTI22158906
hsa-miR-146a-5pMIMAT0000449MIRT001919Luciferase reporter assayFunctional MTI18660546
hsa-miR-128-3pMIMAT0000424MIRT022036MicroarrayFunctional MTI (Weak)17612493
hsa-miR-122-5pMIMAT0000421MIRT023360MicroarrayFunctional MTI (Weak)17612493
hsa-miR-215-5pMIMAT0000272MIRT024347MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026685MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22019631In this review the tumor suppressor genes p53, FoxO, retinoblastoma (RB), p21, p16, and breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2) and their roles in oxidative stress are summarized with a focus on the links and interplay between their pathways and reactive oxygen species (ROS)
19836377Cancers with nonfunctional BRCA1 and BRCA2 are particularly sensitive to combined treatment with DNA damaging drugs and inhibitors of poly(ADP-ribose) polymerase
17700066The higher load of DNA damage may also contribute to cancer predisposition in families with inherited heterozygous defects in the DDR barrier, such as in ATM, BRCA1, BRCA2, p53 and other genes
15781639The TBX2 gene encoding a key developmental transcription factor is amplified in pancreatic cancer cell lines and preferentially amplified and overexpressed in BRCA1 and BRCA2 mutated breast tumors
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