HCSGD entry for TAL1

1. General information

Official gene symbolTAL1
Entrez ID6886
Gene full nameT-cell acute lymphocytic leukemia 1
Other gene symbolsSCL TCL5 bHLHa17 tal-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000118Histone deacetylase complexIDAcellular_component
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0001525AngiogenesisIEAbiological_process
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIDAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0021527Spinal cord association neuron differentiationIEAbiological_process
GO:0030097HemopoiesisISSbiological_process
GO:0030218Erythrocyte differentiationIEP IMPbiological_process
GO:0030219Megakaryocyte differentiationIEPbiological_process
GO:0030220Platelet formationIEAbiological_process
GO:0030221Basophil differentiationIEPbiological_process
GO:0031334Positive regulation of protein complex assemblyIDAbiological_process
GO:0033193Lsd1/2 complexIDAcellular_component
GO:0035162Embryonic hemopoiesisISSbiological_process
GO:0035855Megakaryocyte developmentIEAbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043249Erythrocyte maturationIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0045165Cell fate commitmentISSbiological_process
GO:0045648Positive regulation of erythrocyte differentiationIDA ISSbiological_process
GO:0045799Positive regulation of chromatin assembly or disassemblyIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045931Positive regulation of mitotic cell cycleIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0051781Positive regulation of cell divisionIMPbiological_process
GO:0060018Astrocyte fate commitmentIEAbiological_process
GO:0060216Definitive hemopoiesisIEAbiological_process
GO:0060217Hemangioblast cell differentiationIEAbiological_process
GO:0060218Hematopoietic stem cell differentiationIEAbiological_process
GO:0060375Regulation of mast cell differentiationIEAbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:2000036Regulation of stem cell maintenanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74062799290.80946397170.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0020221592
GSE13712_SHEARUp0.1037479638
GSE13712_STATICDown-0.2559736648
GSE19018Down-0.0421449892
GSE19899_A1Up0.0080882506
GSE19899_A2Up0.0273165672
PubMed_21979375_A1Up0.0270143249
PubMed_21979375_A2Down-0.0507194114
GSE35957Up0.1451750986
GSE36640Up0.0221768682
GSE54402Up0.0680811121
GSE9593Up0.0094823982
GSE43922Up0.0298549591
GSE24585Down-0.0784983098
GSE37065Down-0.0777441033
GSE28863_A1Down-0.0252411262
GSE28863_A2Down-0.0496211600
GSE28863_A3Up0.3169197068
GSE28863_A4Up0.1681596057
GSE48662Up0.0607871882

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

260026841, and TAL1, which are master regulators (MRs) for the age-dependent microglia module
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