HCSGD entry for TBCE
1. General information
| Official gene symbol | TBCE |
|---|---|
| Entrez ID | 6905 |
| Gene full name | tubulin folding cofactor E |
| Other gene symbols | HRD KCS KCS1 pac2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000226 | Microtubule cytoskeleton organization | IEA | biological_process |
| GO:0003735 | Structural constituent of ribosome | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005840 | Ribosome | IEA | cellular_component |
| GO:0005874 | Microtubule | TAS | cellular_component |
| GO:0006412 | Translation | IEA | biological_process |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0007023 | Post-chaperonin tubulin folding pathway | IDA | biological_process |
| GO:0008344 | Adult locomotory behavior | IEA | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0014889 | Muscle atrophy | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0048589 | Developmental growth | IEA | biological_process |
| GO:0048936 | Peripheral nervous system neuron axonogenesis | IEA | biological_process |
| GO:0051084 | 'de novo' posttranslational protein folding | TAS | biological_process |
| GO:0051087 | Chaperone binding | TAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4382437331 | 0.1839069754 | 0.9999902473 | 0.8315322171 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1600515837 |
| GSE13712_SHEAR | Up | 0.6036968769 |
| GSE13712_STATIC | Up | 0.6061791327 |
| GSE19018 | Down | -0.1620991997 |
| GSE19899_A1 | Up | 0.1213492800 |
| GSE19899_A2 | Up | 0.2384307354 |
| PubMed_21979375_A1 | Up | 0.0936712210 |
| PubMed_21979375_A2 | Down | -0.4630344727 |
| GSE35957 | Down | -0.5972263176 |
| GSE36640 | Down | -0.3805207866 |
| GSE54402 | Up | 0.3034797604 |
| GSE9593 | Up | 0.2046202045 |
| GSE43922 | Up | 0.0189105302 |
| GSE24585 | Up | 0.0423701036 |
| GSE37065 | Down | -0.2322798241 |
| GSE28863_A1 | Down | -0.4279152287 |
| GSE28863_A2 | Up | 0.3061035688 |
| GSE28863_A3 | Down | -0.5445550224 |
| GSE28863_A4 | Down | -0.1137245625 |
| GSE48662 | Down | -0.4093581886 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-423-3p | MIMAT0001340 | MIRT042552 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15126325 | Changes in expression of different senescence-associated genes were analyzed in cultured human skin keratinocytes (KCs) that underwent replicative senescence or confluence-induced accelerated senescence |
| 15126325 | Immunohistochemical analysis of 14 normal human skin samples (age range from 3 months to 84 years) showed that maspin is expressed by KCs in vivo and that the extent and intensity of maspin expression in the skin is significantly (P = 0 |
| 15126325 | Antiangiogenic activity of maspin secreted by senescent KCs was investigated in vitro by testing the effect of conditioned media from different KC cultures on endothelial cell migration in the presence or absence of several angiogenic factors |
| 15126325 | Media conditioned by senescent cultures (undergoing replicative or accelerated senescence), but not by proliferating KCs, strongly inhibited the stimulation of endothelial cell migration by all of the tested angiogenic factors |
| 15126325 | These findings indicate that senescent KCs exert a paracrine antiangiogenic activity, and maspin is the principal contributor to this potentially tumor-suppressive effect of cellular senescence |
| 12507899 | During malignant transformation in skin, epidermal keratinocytes (KCs) frequently acquire the capacity to by-pass cellular senescence, a response that normally limits their unrestricted proliferation |
| 12507899 | In this study, several molecular pathways are explored using cultured KCs and KCs freshly isolated from psoriatic plaques |
| 12507899 | Although abnormal mitogenic signaling by oncogenic Ras is generally cited as being responsible for induction of premature senescence, our findings indicate that a broader perspective is warranted, to include confluency and cytokine-/TPA-induced pathways for KCs |
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