HCSGD entry for TCEB3
1. General information
| Official gene symbol | TCEB3 |
|---|---|
| Entrez ID | 6924 |
| Gene full name | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) |
| Other gene symbols | EloA SIII SIII p110 TCEB3A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006368 | Transcription elongation from RNA polymerase II promoter | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0050434 | Positive regulation of viral transcription | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0210692793 | 0.9758437673 | 0.3498258512 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3379877553 |
| GSE13712_SHEAR | Up | 0.3291421223 |
| GSE13712_STATIC | Up | 0.1990720576 |
| GSE19018 | Down | -0.3264976615 |
| GSE19899_A1 | Up | 0.1174965804 |
| GSE19899_A2 | Up | 0.5502816702 |
| PubMed_21979375_A1 | Up | 1.1454967128 |
| PubMed_21979375_A2 | Up | 0.9295680331 |
| GSE35957 | Up | 0.1507291640 |
| GSE36640 | Up | 0.3241982872 |
| GSE54402 | Up | 0.2610434858 |
| GSE9593 | Up | 0.1588447663 |
| GSE43922 | Up | 0.5776796580 |
| GSE24585 | Up | 0.2929871528 |
| GSE37065 | Up | 0.0678323424 |
| GSE28863_A1 | Up | 0.0819369666 |
| GSE28863_A2 | Up | 0.3689466005 |
| GSE28863_A3 | Down | -0.0196973901 |
| GSE28863_A4 | Down | -0.1169451120 |
| GSE48662 | Down | -0.2336673062 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024881 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026940 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-320b | MIMAT0005792 | MIRT036200 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041516 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041964 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051374 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17170753 | Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A |
| 17170753 | Elongin A is a transcription elongation factor that increases the overall rate of mRNA chain elongation by RNA polymerase II |
| 17170753 | To gain more insight into the physiological functions of Elongin A, we generated Elongin A-deficient mice |
| 17170753 | Elongin A homozygous mutant (Elongin A(-/-)) embryos demonstrated a severely retarded development and died at between days 10 |
| 17170753 | Knockdown of Elongin A in MEFs by RNA interference also dramatically induced the senescent phenotype |
| 17170753 | Taken together, our results suggest that Elongin A is required for the transcription of genes essential for early embryonic development and downregulation of its activity is tightly associated with cellular senescence |
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