HCSGD entry for TGFB3

1. General information

Official gene symbolTGFB3
Entrez ID7043
Gene full nametransforming growth factor, beta 3
Other gene symbolsARVD TGF-beta3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIEAbiological_process
GO:0001666Response to hypoxiaIDA IEAbiological_process
GO:0001701In utero embryonic developmentIEA ISSbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0005114Type II transforming growth factor beta receptor bindingIDA IPImolecular_function
GO:0005160Transforming growth factor beta receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneICcellular_component
GO:0007179Transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0007184SMAD protein import into nucleusIEAbiological_process
GO:0007435Salivary gland morphogenesisIEPbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008156Negative regulation of DNA replicationIMPbiological_process
GO:0008285Negative regulation of cell proliferationIEA ISSbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDA IEA ISSbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIEA ISSbiological_process
GO:0010936Negative regulation of macrophage cytokine productionIDAbiological_process
GO:0016049Cell growthIEAbiological_process
GO:0022601Menstrual cycle phaseIEPbiological_process
GO:0030141Secretory granuleIEAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030315T-tubuleIEAcellular_component
GO:0030501Positive regulation of bone mineralizationIEPbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0030879Mammary gland developmentIEA ISSbiological_process
GO:0031012Extracellular matrixIDA IEAcellular_component
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0032570Response to progesteroneIDAbiological_process
GO:0032967Positive regulation of collagen biosynthetic processIMPbiological_process
GO:0034616Response to laminar fluid shear stressIEAbiological_process
GO:0034713Type I transforming growth factor beta receptor bindingIDAmolecular_function
GO:0042060Wound healingIEAbiological_process
GO:0042476OdontogenesisNASbiological_process
GO:0042802Identical protein bindingIDAmolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043065Positive regulation of apoptotic processIEA ISSbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEA ISSbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0043932Ossification involved in bone remodelingIEPbiological_process
GO:0045216Cell-cell junction organizationIDAbiological_process
GO:0045740Positive regulation of DNA replicationIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048286Lung alveolus developmentIEA ISSbiological_process
GO:0048565Digestive tract developmentIEAbiological_process
GO:0048702Embryonic neurocranium morphogenesisIEAbiological_process
GO:0048839Inner ear developmentIEAbiological_process
GO:0050431Transforming growth factor beta bindingIDAmolecular_function
GO:0050714Positive regulation of protein secretionIDAbiological_process
GO:0051491Positive regulation of filopodium assemblyIEA ISSbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0060021Palate developmentIEA ISSbiological_process
GO:0060325Face morphogenesisIEA IMPbiological_process
GO:0060364Frontal suture morphogenesisIEAbiological_process
GO:0060391Positive regulation of SMAD protein import into nucleusIEA ISSbiological_process
GO:0070483Detection of hypoxiaIDAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70523289390.41796628170.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0668725522
GSE13712_SHEARDown-0.3280397191
GSE13712_STATICDown-0.2021983289
GSE19018Down-0.3313108846
GSE19899_A1Up0.0665689810
GSE19899_A2Up0.1212173846
PubMed_21979375_A1Down-0.2009279711
PubMed_21979375_A2Down-0.0527016240
GSE35957Down-0.0034380722
GSE36640Down-0.0684782669
GSE54402Down-0.1153095283
GSE9593Up0.0309168048
GSE43922Up0.0216194800
GSE24585Up0.0157918533
GSE37065Up0.4954735981
GSE28863_A1Up0.0381149869
GSE28863_A2Up0.1211498697
GSE28863_A3Up0.3130276498
GSE28863_A4Up0.0301900718
GSE48662Down-0.2756605154

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

1,4-Diethylene DioxideDB03316 EXPT01208

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29a-3pMIMAT0000086MIRT005910qRT-PCRFunctional MTI (Weak)21169019
hsa-miR-10a-5pMIMAT0000253MIRT047598CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25279424Members of the TGF-beta superfamily, TGF-beta1, TGF-beta3, and BMP9, are key propagators of both inhibition and initiation of angiogenesis
20551174Lymphomas that arise express high amounts of transforming growth factor beta-2 (TGFbeta-2) and TGFbeta-3
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