HCSGD entry for TK2
1. General information
| Official gene symbol | TK2 |
|---|---|
| Entrez ID | 7084 |
| Gene full name | thymidine kinase 2, mitochondrial |
| Other gene symbols | MTDPS2 MTTK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004137 | Deoxycytidine kinase activity | IEA | molecular_function |
| GO:0004797 | Thymidine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006139 | Nucleobase-containing compound metabolic process | IEA TAS | biological_process |
| GO:0006206 | Pyrimidine nucleobase metabolic process | TAS | biological_process |
| GO:0006264 | Mitochondrial DNA replication | IEA | biological_process |
| GO:0009157 | Deoxyribonucleoside monophosphate biosynthetic process | TAS | biological_process |
| GO:0009165 | Nucleotide biosynthetic process | TAS | biological_process |
| GO:0009262 | Deoxyribonucleotide metabolic process | IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0016773 | Phosphotransferase activity, alcohol group as acceptor | IEA | molecular_function |
| GO:0043097 | Pyrimidine nucleoside salvage | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046092 | Deoxycytidine metabolic process | IEA | biological_process |
| GO:0046104 | Thymidine metabolic process | IEA | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0372420159 | 0.8905387789 | 0.4364015514 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1704061079 |
| GSE13712_SHEAR | Down | -0.4854686041 |
| GSE13712_STATIC | Down | -0.1266476409 |
| GSE19018 | Up | 0.1122436478 |
| GSE19899_A1 | Up | 0.0669273884 |
| GSE19899_A2 | Up | 0.6234486135 |
| PubMed_21979375_A1 | Down | -0.4497543510 |
| PubMed_21979375_A2 | Up | 0.2765047953 |
| GSE35957 | Up | 0.1479259074 |
| GSE36640 | Up | 1.2884834573 |
| GSE54402 | Down | -0.1555166073 |
| GSE9593 | Up | 0.5645217360 |
| GSE43922 | Up | 0.0067935682 |
| GSE24585 | Up | 0.5392280720 |
| GSE37065 | Down | -0.0488021708 |
| GSE28863_A1 | Up | 0.5762206471 |
| GSE28863_A2 | Up | 0.0960169283 |
| GSE28863_A3 | Up | 0.1799179252 |
| GSE28863_A4 | Down | -0.0204923364 |
| GSE48662 | Up | 0.5823200914 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Thymidine-5'-Triphosphate | DB02452 | EXPT03131 |
| 2'-Deoxycytidine | DB02594 | EXPT01140 |
| Deoxythymidine | DB04485 | EXPT03053 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017549 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
