HCSGD entry for TXNRD1

1. General information

Official gene symbolTXNRD1
Entrez ID7296
Gene full namethioredoxin reductase 1
Other gene symbolsGRIM-12 TR TR1 TRXR1 TXNR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001707Mesoderm formationIEAbiological_process
GO:0004791Thioredoxin-disulfide reductase activityEXP IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0007165Signal transductionNASbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0009055Electron carrier activityIEAmolecular_function
GO:0015035Protein disulfide oxidoreductase activityIEAmolecular_function
GO:0015949Nucleobase-containing small molecule interconversionTASbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045454Cell redox homeostasisIEAbiological_process
GO:0050660Flavin adenine dinucleotide bindingIEAmolecular_function
GO:0050661NADP bindingIEAmolecular_function
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20018173700.51446779000.86287538461.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0274805186
GSE13712_SHEARUp0.4797434854
GSE13712_STATICUp0.5236311353
GSE19018Down-0.0465325555
GSE19899_A1Down-0.1873295424
GSE19899_A2Down-0.0995684523
PubMed_21979375_A1Up0.3150069357
PubMed_21979375_A2Up0.0831022391
GSE35957Up0.6206025087
GSE36640Up0.3461350813
GSE54402Up0.0050282704
GSE9593Up0.3563109666
GSE43922Down-0.1487238286
GSE24585Down-0.2809771757
GSE37065Down-0.0529096605
GSE28863_A1Up0.0808919057
GSE28863_A2Down-0.4239476413
GSE28863_A3Down-0.3339285861
GSE28863_A4Up0.0442834540
GSE48662Up0.3100137843

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL405110CHEMBL19279Q16881
CHEMBL1089316CHEMBL19278Q16881
CHEMBL120147CHEMBL19275Q16881
CHEMBL120147CHEMBL19275Q16881
CHEMBL383084CHEMBL19275Q16881
CHEMBL198157CHEMBL19275Q16881
CHEMBL206140CHEMBL19275Q16881
CHEMBL206829CHEMBL19275Q16881
CHEMBL206713CHEMBL19275Q16881
CHEMBL144530CHEMBL19275Q16881
CHEMBL274056CHEMBL19275Q16881
CHEMBL120147CHEMBL19275Q16881
CHEMBL204688CHEMBL19275Q16881
CHEMBL89475CHEMBL19274Q16881
CHEMBL91371CHEMBL19274Q16881
CHEMBL88230CHEMBL19274Q16881
CHEMBL313317CHEMBL19274Q16881
CHEMBL91726CHEMBL19274Q16881
CHEMBL91078CHEMBL19274Q16881
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  • Drugs

Name

Drug

Accession number

Nadph Dihydro-Nicotinamide-Adenine-DinucleotidephosphateDB02338 EXPT02321
SpermidineDB03566 EXPT02942
FotemustineDB04106 EXPT03300
motexafin gadoliniumDB05428 -
PX-12DB05448 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT001489pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-186-5pMIMAT0000456MIRT021121SequencingFunctional MTI (Weak)20371350
hsa-miR-34a-5pMIMAT0000255MIRT025447ProteomicsFunctional MTI (Weak)21566225
hsa-miR-26b-5pMIMAT0000083MIRT029399MicroarrayFunctional MTI (Weak)19088304
hsa-miR-504-5pMIMAT0002875MIRT041077CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051614CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

2327400177 (nmol/min/mg protein) and upregulated the gene expression levels of copper transport protein ATOX1, glutathione synthetase (GSS) and thioredoxin reductase 1 (TXNRD1) while down-regulated aldehyde oxidase 1 (AOX1)
19820694Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence
19820694Thioredoxin reductase 1 (TrxR1) is an important antioxidant enzyme that controls cellular redox homeostasis
19820694By using a proteomic-based approach, here we identify TrxR1 as a caveolar membrane-resident protein
19820694We show that caveolin 1, the structural protein component of caveolae, is a TrxR1-binding protein by demonstrating that the scaffolding domain of caveolin 1 (amino acids 82-101) binds directly to the caveolin-binding motif (CBM) of TrxR1 (amino acids 454-463)
19820694A TrxR1 mutant lacking the CBM, which fails to localize to caveolae and bind to caveolin 1, is constitutively active and inhibits oxidative-stress-mediated activation of the p53/p21(Waf1/Cip1) pathway and induction of premature senescence
19820694Thus, caveolin 1 links free radicals to activation of the p53/p21(Waf1/Cip1) pathway and induction of cellular senescence by acting as an endogenous inhibitor of TrxR1
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