HCSGD entry for IRG1

1. General information

Official gene symbolIRG1
Entrez ID730249
Gene full nameimmunoresponsive 1 homolog (mouse)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002760Positive regulation of antimicrobial humoral responseIDAbiological_process
GO:0005739MitochondrionISScellular_component
GO:0006952Defense responseIDAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007566Embryo implantationISSbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0019543Propionate catabolic processIEAbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityISSbiological_process
GO:0032480Negative regulation of type I interferon productionISSbiological_process
GO:0034136Negative regulation of toll-like receptor 2 signaling pathwayISSbiological_process
GO:0034144Negative regulation of toll-like receptor 4 signaling pathwayISSbiological_process
GO:0035458Cellular response to interferon-betaISSbiological_process
GO:0045824Negative regulation of innate immune responseISSbiological_process
GO:00475472-methylcitrate dehydratase activityIEAmolecular_function
GO:0047613Aconitate decarboxylase activityIDAmolecular_function
GO:0050728Negative regulation of inflammatory responseISSbiological_process
GO:0071219Cellular response to molecule of bacterial originISSbiological_process
GO:0071222Cellular response to lipopolysaccharideIDAbiological_process
GO:0071346Cellular response to interferon-gammaISSbiological_process
GO:0071347Cellular response to interleukin-1ISSbiological_process
GO:0071356Cellular response to tumor necrosis factorISSbiological_process
GO:0071393Cellular response to progesterone stimulusISSbiological_process
GO:0072573Tolerance induction to lipopolysaccharideIDAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06173022680.97472851720.53837021211.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0554552132
GSE13712_SHEARUp0.1638777771
GSE13712_STATICUp0.0714506271
GSE19018Up0.0723681139
GSE19899_A1Up0.0030533252
GSE19899_A2Up0.9052013412
PubMed_21979375_A1Up0.7978614286
PubMed_21979375_A2Up0.6637358896
GSE35957Up0.1513896080
GSE36640Down-0.1783737325
GSE54402Up0.5716770986
GSE9593Down-0.0426567331
GSE43922Up0.3764527290
GSE24585Up0.2375256087
GSE37065Up0.0116748151
GSE28863_A1Down-0.0197092608
GSE28863_A2Down-0.0753616612
GSE28863_A3Up0.1194667777
GSE28863_A4Up0.0574086310
GSE48662--

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.