HCSGD entry for UMPS


1. General information

Official gene symbolUMPS
Entrez ID7372
Gene full nameuridine monophosphate synthetase
Other gene symbolsOPRT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004588Orotate phosphoribosyltransferase activityIDA IEA TASmolecular_function
GO:0004590Orotidine-5'-phosphate decarboxylase activityIDA IEA TASmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006206Pyrimidine nucleobase metabolic processTASbiological_process
GO:0006207'de novo' pyrimidine nucleobase biosynthetic processIEAbiological_process
GO:0006221Pyrimidine nucleotide biosynthetic processIEAbiological_process
GO:0006222UMP biosynthetic processIDAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0009116Nucleoside metabolic processIEAbiological_process
GO:0016740Transferase activityIEAmolecular_function
GO:0035690Cellular response to drugIEAbiological_process
GO:0044205'de novo' UMP biosynthetic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046134Pyrimidine nucleoside biosynthetic processTASbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09821370390.69063934120.65397918041.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0930761702
GSE13712_SHEARUp0.0218006068
GSE13712_STATICUp0.1819671370
GSE19018Down-0.4684628022
GSE19899_A1Up0.2185782936
GSE19899_A2Up0.3052111733
PubMed_21979375_A1Up0.8332960081
PubMed_21979375_A2Up0.1282403552
GSE35957Down-0.0147092741
GSE36640Down-0.4215778975
GSE54402Up0.2920936954
GSE9593Down-0.3563662982
GSE43922Up0.3871772775
GSE24585Down-0.3958754535
GSE37065Down-0.0606378091
GSE28863_A1Up0.5425076525
GSE28863_A2Up0.6787629437
GSE28863_A3Up0.2837719712
GSE28863_A4Down-0.0721929818
GSE48662Down-0.3294094183

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

6-Hydroxyuridine-5'-PhosphateDB02890 EXPT00724

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT004213MicroarrayFunctional MTI (Weak)16822819
hsa-miR-124-3pMIMAT0000422MIRT022649MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.