HCSGD entry for UNG

1. General information

Official gene symbolUNG
Entrez ID7374
Gene full nameuracil-DNA glycosylase
Other gene symbolsDGU HIGM4 HIGM5 UDG UNG1 UNG15 UNG2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004844Uracil DNA N-glycosylase activityIEA NASmolecular_function
GO:0005634NucleusNAScellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006284Base-excision repairIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016446Somatic hypermutation of immunoglobulin genesIEAbiological_process
GO:0016447Somatic recombination of immunoglobulin gene segmentsIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60908839330.31172076670.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0243812942
GSE13712_SHEARUp0.0400433518
GSE13712_STATICUp0.0456119197
GSE19018Down-0.1502523200
GSE19899_A1Down-0.1687639039
GSE19899_A2Up0.1393710799
PubMed_21979375_A1Down-0.3756576890
PubMed_21979375_A2Down-0.2771543610
GSE35957Down-0.1423573890
GSE36640Down-0.7662096210
GSE54402Down-0.1315892735
GSE9593Up0.2398809791
GSE43922Up0.0135731978
GSE24585Down-0.2541345683
GSE37065Down-0.0193468609
GSE28863_A1Up0.6003909612
GSE28863_A2Up0.4305710674
GSE28863_A3Up0.0980991192
GSE28863_A4Up0.0081547321
GSE48662Up0.2017168993

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACIDDB06990 -
1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLEDB07116 -
3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acidDB07760 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT007301Luciferase reporter assayFunctional MTI23228472
hsa-miR-34c-5pMIMAT0000686MIRT007302Luciferase reporter assayFunctional MTI23228472
hsa-miR-199a-5pMIMAT0000231MIRT007303Luciferase reporter assayFunctional MTI23228472
hsa-miR-215-5pMIMAT0000272MIRT024454MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026620MicroarrayFunctional MTI (Weak)19074876
hsa-miR-24-3pMIMAT0000080MIRT030474MicroarrayFunctional MTI (Weak)19748357
hsa-miR-129-2-3pMIMAT0004605MIRT038623CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT045987CLASHFunctional MTI (Weak)23622248
hsa-miR-28-5pMIMAT0000085MIRT049999CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

1379342Specific activities of the glycosylase that releases various modified pyrimidines and of uracil-DNA glycosylase (which removes uracil from DNA) were essentially the same in all cell lines
2366800Specific activities of the glycosylase that releases ring-saturated pyrimidines and of uracil-DNA glycosylase were not substantially altered in senescent cells
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