HCSGD entry for USP4
1. General information
| Official gene symbol | USP4 |
|---|---|
| Entrez ID | 7375 |
| Gene full name | ubiquitin specific peptidase 4 (proto-oncogene) |
| Other gene symbols | UNP Unph |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004221 | Ubiquitin thiolesterase activity | IEA IMP | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005764 | Lysosome | TAS | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0016579 | Protein deubiquitination | IDA IEA | biological_process |
| GO:0031397 | Negative regulation of protein ubiquitination | IMP | biological_process |
| GO:0031647 | Regulation of protein stability | IDA | biological_process |
| GO:0031685 | Adenosine receptor binding | IPI | molecular_function |
| GO:0034394 | Protein localization to cell surface | IDA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5661048896 | 0.3877234414 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3105785174 |
| GSE13712_SHEAR | Down | -0.0308035381 |
| GSE13712_STATIC | Up | 0.1247793847 |
| GSE19018 | Up | 0.1626953287 |
| GSE19899_A1 | Up | 0.1099972151 |
| GSE19899_A2 | Up | 0.1465358529 |
| PubMed_21979375_A1 | Up | 0.1898888125 |
| PubMed_21979375_A2 | Up | 0.0219504837 |
| GSE35957 | Down | -0.3225223671 |
| GSE36640 | Down | -0.0370443315 |
| GSE54402 | Down | -0.0226777960 |
| GSE9593 | Down | -0.1699698368 |
| GSE43922 | Down | -0.1186972749 |
| GSE24585 | Up | 0.4328106166 |
| GSE37065 | Up | 0.0018683933 |
| GSE28863_A1 | Up | 0.1146721695 |
| GSE28863_A2 | Down | -0.0900181319 |
| GSE28863_A3 | Down | -0.5923830714 |
| GSE28863_A4 | Down | -0.2985217430 |
| GSE48662 | Down | -0.0994082000 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21522127 | USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 |
| 21522127 | In this study, we identified ubiquitin-specific peptidase 4 (USP4) as an important regulator of p53 |
| 21522127 | USP4 interacts directly with and deubiquitinates ARF-BP1, leading to the stabilization of ARF-BP1 and subsequent reduction of p53 levels |
| 21522127 | Usp4 knockout mice are viable and developmentally normal, but showed enhanced apoptosis in thymus and spleen in response to ionizing radiation |
| 21522127 | Compared with wild-type mouse embryonic fibroblasts (MEFs), Usp4-/- MEFs exhibited retarded growth, premature cellular senescence, resistance to oncogenic transformation, and hyperactive DNA damage checkpoints, consistent with upregulated levels and activity of p53 in the absence of USP4 |
| 21522127 | Finally, we showed that USP4 is overexpressed in several types of human cancer, suggesting that USP4 is a potential oncogene |
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