HCSGD entry for VAV1

1. General information

Official gene symbolVAV1
Entrez ID7409
Gene full namevav 1 guanine nucleotide exchange factor
Other gene symbolsVAV
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityEXP TASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007264Small GTPase mediated signal transductionIEA TASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030676Rac guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0031295T cell costimulationTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045785Positive regulation of cell adhesionIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:2001141Regulation of RNA biosynthetic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66202996090.68222824360.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0026788725
GSE13712_SHEARDown-0.0291298294
GSE13712_STATICDown-0.2974108694
GSE19018Up0.1434176422
GSE19899_A1Down-0.0649316493
GSE19899_A2Down-0.2189661811
PubMed_21979375_A1Down-0.4198124964
PubMed_21979375_A2Up0.2250049216
GSE35957Up0.0023497483
GSE36640Down-0.0649301964
GSE54402Up0.0419471034
GSE9593Up0.1100602675
GSE43922Up0.0168543487
GSE24585Up0.5687090291
GSE37065Up0.0433224381
GSE28863_A1Down-0.1522494431
GSE28863_A2Down-0.1243359764
GSE28863_A3Up0.2339664162
GSE28863_A4Up0.1018451071
GSE48662Up0.0215365016

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029179MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.