HCSGD entry for VCL
1. General information
| Official gene symbol | VCL |
|---|---|
| Entrez ID | 7414 |
| Gene full name | vinculin |
| Other gene symbols | CMD1W CMH15 MV MVCL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002009 | Morphogenesis of an epithelium | IMP | biological_process |
| GO:0002162 | Dystroglycan binding | IPI | molecular_function |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0003779 | Actin binding | IDA | molecular_function |
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005911 | Cell-cell junction | ISS | cellular_component |
| GO:0005912 | Adherens junction | ISS | cellular_component |
| GO:0005913 | Cell-cell adherens junction | IDA | cellular_component |
| GO:0005916 | Fascia adherens | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IDA IEA ISS | cellular_component |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0007155 | Cell adhesion | IEA TAS | biological_process |
| GO:0007160 | Cell-matrix adhesion | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008013 | Beta-catenin binding | ISS | molecular_function |
| GO:0015629 | Actin cytoskeleton | IEA | cellular_component |
| GO:0030032 | Lamellipodium assembly | IEA ISS | biological_process |
| GO:0030055 | Cell-substrate junction | NAS | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030334 | Regulation of cell migration | IEA | biological_process |
| GO:0030336 | Negative regulation of cell migration | TAS | biological_process |
| GO:0034333 | Adherens junction assembly | IMP | biological_process |
| GO:0034394 | Protein localization to cell surface | IMP | biological_process |
| GO:0043034 | Costamere | IDA IEA ISS | cellular_component |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0043297 | Apical junction assembly | IMP | biological_process |
| GO:0045294 | Alpha-catenin binding | IPI | molecular_function |
| GO:0045296 | Cadherin binding | ISS | molecular_function |
| GO:0090136 | Epithelial cell-cell adhesion | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9701207971 | 0.0241213594 | 0.9999902473 | 0.2989163371 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3121925410 |
| GSE13712_SHEAR | Down | -0.0274793244 |
| GSE13712_STATIC | Up | 0.0432704301 |
| GSE19018 | Down | -0.3407422689 |
| GSE19899_A1 | Down | -0.2061487423 |
| GSE19899_A2 | Down | -0.3667404525 |
| PubMed_21979375_A1 | Down | -0.8558420633 |
| PubMed_21979375_A2 | Down | -0.0010031344 |
| GSE35957 | Up | 0.1339110111 |
| GSE36640 | Down | -0.2716734005 |
| GSE54402 | Down | -1.3539608417 |
| GSE9593 | Down | -0.0372866966 |
| GSE43922 | Down | -0.1342791177 |
| GSE24585 | Down | -0.0706694504 |
| GSE37065 | Down | -0.1447508804 |
| GSE28863_A1 | Up | 0.4606577233 |
| GSE28863_A2 | Down | -0.1187098244 |
| GSE28863_A3 | Down | -0.0936565928 |
| GSE28863_A4 | Down | -0.0237662076 |
| GSE48662 | Down | -0.5145684075 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-661 | MIMAT0003324 | MIRT004114 | Western blot | Non-Functional MTI | 19584269 |
| hsa-miR-559 | MIMAT0003223 | MIRT004115 | Western blot | Non-Functional MTI | 19584269 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025522 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-320b | MIMAT0005792 | MIRT036206 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-130b-5p | MIMAT0004680 | MIRT038322 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044534 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045944 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046654 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048250 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051181 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 7796463 | To shed light on the relationship between functions of the cytoskeleton and senescence or immortalization, we investigated the alterations in gene expression after immortalization and measured the amounts of mRNAs for talin, vinculin, alpha-actinin, tropomyosin 1 (TM1), vimentin, lamin A and C, and alpha-tubulin by slot blot and Northern blot analyses |
| 7796463 | We found that the mRNAs for vinculin and vimentin were reduced and the mRNA for lamin A was increased in immortalized cells |
| 7796463 | Vinculin, tropomyosins and vimentin showed their altered distributions in immortalized cells |
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