HCSGD entry for CACNB4

1. General information

Official gene symbolCACNB4
Entrez ID785
Gene full namecalcium channel, voltage-dependent, beta 4 subunit
Other gene symbolsCAB4 CACNLB4 EA5 EIG9 EJM EJM4 EJM6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005245Voltage-gated calcium channel activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005891Voltage-gated calcium channel complexIDA IEAcellular_component
GO:0006810TransportIDA TASbiological_process
GO:0006812Cation transportIDAbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0007214Gamma-aminobutyric acid signaling pathwayIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008331High voltage-gated calcium channel activityIDAmolecular_function
GO:0009898Cytoplasmic side of plasma membraneTAScellular_component
GO:0014051Gamma-aminobutyric acid secretionIEAbiological_process
GO:0019227Neuronal action potential propagationIEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030001Metal ion transportIDAbiological_process
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0045202SynapseIDAcellular_component
GO:0046058CAMP metabolic processIEAbiological_process
GO:0048536Spleen developmentIEAbiological_process
GO:0048538Thymus developmentIEAbiological_process
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0048747Muscle fiber developmentIEAbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0050908Detection of light stimulus involved in visual perceptionIEAbiological_process
GO:0051049Regulation of transportIDAbiological_process
GO:0051899Membrane depolarizationTASbiological_process
GO:0055085Transmembrane transportIDAbiological_process
GO:0070588Calcium ion transmembrane transportIDAbiological_process
GO:0072511Divalent inorganic cation transportIDAbiological_process
GO:1901385Regulation of voltage-gated calcium channel activityIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01928232590.94262501420.33812798131.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0614168670
GSE13712_SHEARDown-0.2187522757
GSE13712_STATICDown-0.0781018655
GSE19018Up0.3120075648
GSE19899_A1Up0.1898114705
GSE19899_A2Up0.2390542163
PubMed_21979375_A1Up0.1217127617
PubMed_21979375_A2Up0.0880529826
GSE35957Up1.6673654309
GSE36640Up0.0015327000
GSE54402Down-0.0319458191
GSE9593Up0.0395308966
GSE43922Up0.0722365120
GSE24585Down-0.2046450854
GSE37065Up0.3751021160
GSE28863_A1Up1.2438749209
GSE28863_A2Up0.1505182094
GSE28863_A3Up0.2848528635
GSE28863_A4Up0.4815080895
GSE48662Up0.2998591066

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

VerapamilDB00661 APRD00335
MibefradilDB01388 -
DronedaroneDB04855 -
SpironolactoneDB00421 APRD01234

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030091SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.